Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | TNF | P01375 | 1/20 | 0.52 |
| ▸ | GALR3 | O60755 | 3/20 | 0.52 |
| ▸ | NR2F2 | P24468 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | GFER | P55789 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL540958 | 0.84 | TNF (0.73) | MEN1KMT2ATNFGALR3NR2F2 | |
| SCHEMBL6806024 | 0.83 | LMNA (0.51) | MEN1KMT2ALMNAKDM4EPOLB | |
| SCHEMBL3397633 | 0.79 | LMNA (0.61) | MEN1KMT2ARAB9ALMNATP53 | |
| SCHEMBL6446137 | 0.78 | LMNA (0.69) | TNFGALR3NR2F2RAB9APKM | |
| SCHEMBL27875060 | 0.77 | TNF (0.58) | TNFGALR3NR2F2RAB9APKM | |
| SCHEMBL760728 | 0.76 | PKM (0.60) | TNFGALR3NR2F2RAB9APKM | |
| SCHEMBL2330274 | 0.74 | LMNA (0.69) | TNFGALR3NR2F2RAB9APKM | |
| SCHEMBL229041 | 0.74 | POLB (0.67) | MEN1KMT2ATNFGALR3NR2F2 | |
| SCHEMBL6803832 | 0.73 | HTT (0.70) | KMT2ATNFPKMLMNAHTT | |
| SCHEMBL6805526 | 0.73 | MAPT (0.70) | RAB9AKDM4EMAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6770647-B2 | Bicyclic hydroxamates as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme (TACE) | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2004-08-03 | — | — | US | disclosed |
| WO-2003016248-A2 | BICYCLIC HYDROXAMATES AS INHIBITORS OF MATRIX METALLOPROTEINASES AND/OR TNF-$G(A) CONVERTING ENZYME (TACE) | BRISTOL-MYERS SQUIBB COMPANY PATENT DEPARTMENT (US) | 2003-02-27 | — | — | WO | disclosed |