Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.44 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.44 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.44 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7359851 | 0.94 | ALDH1A1 (0.56) | ALDH1A1CA12CA1CA2CA9 | |
| SCHEMBL7362562 | 0.92 | ALDH1A1 (0.58) | ALDH1A1CA12CA1CA2CA9 | |
| SCHEMBL7359403 | 0.91 | NOX4 (0.47) | ALDH1A1CA12CA1CA2CA9 | |
| SCHEMBL7359573 | 0.90 | ALDH1A1 (0.43) | ALDH1A1CA12CA1CA2CA9 | |
| SCHEMBL9275919 | 0.87 | PDE4D (0.53) | ALDH1A1KMT2AMEN1PDE4APDE4B | |
| SCHEMBL7358841 | 0.80 | CA12 (0.69) | ALDH1A1CA12CA1CA2CA9 | |
| SCHEMBL7348827 | 0.80 | PDE4D (0.52) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9269689 | 0.77 | KMT2A (0.59) | ALDH1A1KMT2AMAPTMEN1LMNA | |
| SCHEMBL7364544 | 0.74 | ALDH1A1 (0.57) | ALDH1A1KMT2APLAAT3PLAAT5PLAAT2 | |
| SCHEMBL7417119 | 0.73 | PDE4B (0.61) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5393788-A | Phenylalkyl oxamides | SMITHKLINE BEECHAM CORPORATION (US) | 1995-02-28 | — | — | US | claimed |
| EP-1466598-A2 | PDE-IV inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 2004-10-13 | — | — | EP | disclosed |
| EP-0710109-B1 | Method for identifying a PDE IV inhibitor | SMITHKLINE BEECHAM CORP (US) | 2004-09-15 | — | — | EP | disclosed |
| US-5393788-A | Phenylalkyl oxamides | SMITHKLINE BEECHAM CORPORATION (US) | 1995-02-28 | — | — | US | disclosed |