Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.53 |
| ▸ | LTA4H | P09960 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 2/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28071588 | 0.86 | LTA4H (0.48) | HRH3LTA4HNPC1CASP3RAB9A | |
| SCHEMBL25846133 | 0.80 | HRH3 (0.49) | HRH3LTA4HNPC1CASP3RAB9A | |
| SCHEMBL17659705 | 0.79 | HTR1A (0.54) | HRH3LTA4HNPC1CASP3RAB9A | |
| SCHEMBL17659018 | 0.78 | HTR1A (0.52) | HRH3LTA4HNPC1CASP3RAB9A | |
| SCHEMBL8321069 | 0.77 | RAB9A (0.50) | HRH3LTA4HNPC1CASP3RAB9A | |
| SCHEMBL11102792 | 0.76 | HRH3 (0.53) | HRH3NPC1RAB9AHTT | |
| SCHEMBL8319330 | 0.76 | NPC1 (0.52) | HRH3LTA4HNPC1CASP3RAB9A | |
| SCHEMBL6702208 | 0.74 | LMNA (0.56) | LTA4HMAOBALOX5HTR1ADRD2 | |
| SCHEMBL8322225 | 0.74 | MAOB (0.58) | HRH3LTA4HMAOBALOX5MAOA | |
| SCHEMBL16046663 | 0.73 | LTA4H (0.62) | HRH3LTA4HNPC1CASP3RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0937458-B1 | Pyrrolidine and piperidine derivatives | HOFFMANN LA ROCHE (CH) | 2004-12-29 | — | — | EP | disclosed |