SCHEMBL6813480

SCHEMBL6813480

COC(=O)c1cccc2c1CC(CN)(CC(=O)O)C2

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TRPA1 O75762 4/20 0.39
ALDH1A1 P00352 5/20 0.37
CFTR P13569 1/20 0.37
HSD17B10 Q99714 1/20 0.37
TSHR P16473 3/20 0.36
HPGD P15428 1/20 0.36
KDM4E B2RXH2 2/20 0.35
LMNA P02545 3/20 0.35
USP2 O75604 1/20 0.35
CYP1A2 P05177 1/20 0.35
BLM P54132 1/20 0.35
CACNA2D1 P54289 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
GAA P10253 1/20 0.34
DRD2 P14416 1/20 0.34
DRD4 P21917 1/20 0.34
DRD3 P35462 1/20 0.34
HTR5A P47898 1/20 0.34
CA1 P00915 1/20 0.34
CA2 P00918 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6817221 0.85 ALDH1A1 (0.39) TRPA1ALDH1A1TSHRHPGDKDM4E
SCHEMBL6818043 0.82 ALDH1A1 (0.39) ALDH1A1HSD17B10TSHRHPGDKDM4E
SCHEMBL6821003 0.81 HPGD (0.39) ALDH1A1HSD17B10TSHRHPGDKDM4E
SCHEMBL6818210 0.80 LMNA (0.39) ALDH1A1TSHRKDM4ELMNAUSP2
SCHEMBL6818045 0.80 ALDH1A1 (0.36) ALDH1A1TSHRHPGDKDM4ELMNA
SCHEMBL6818094 0.79 USP2 (0.40) ALDH1A1TSHRLMNAUSP2CYP1A2
SCHEMBL6813335 0.79 HTR1A (0.48) ALDH1A1TSHRLMNAUSP2CYP1A2
SCHEMBL14459076 0.79 ALDH1A1 (0.40) ALDH1A1TSHRHPGDLMNAUSP2
SCHEMBL6813555 0.78 USP2 (0.39) ALDH1A1TSHRLMNAUSP2CYP1A2
SCHEMBL6813724 0.78 AKR1B1 (0.44) ALDH1A1TSHRLMNAUSP2CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1180094-B1 FUSED POLYCYCLIC AMINO ACIDS AS PHARMACEUTICAL AGENTS WARNER LAMBERT CO (US) 2004-07-28 EP claimed
EP-1180094-A1 FUSED POLYCYCLIC AMINO ACIDS AS PHARMACEUTICAL AGENTS WARNER-LAMBERT COMPANY (US) 2002-02-20 EP claimed
WO-2000073259-A1 FUSED POLYCYCLIC AMINO ACIDS AS PHARMACEUTICAL AGENTS WARNER-LAMBERT COMPANY (US) 2000-12-07 WO claimed
EP-1180094-B1 FUSED POLYCYCLIC AMINO ACIDS AS PHARMACEUTICAL AGENTS WARNER LAMBERT CO (US) 2004-07-28 EP disclosed
EP-1180094-A1 FUSED POLYCYCLIC AMINO ACIDS AS PHARMACEUTICAL AGENTS WARNER-LAMBERT COMPANY (US) 2002-02-20 EP disclosed
WO-2000073259-A1 FUSED POLYCYCLIC AMINO ACIDS AS PHARMACEUTICAL AGENTS WARNER-LAMBERT COMPANY (US) 2000-12-07 WO disclosed