SCHEMBL6818045

SCHEMBL6818045

CNc1cccc2c1CC(CN)(CC(=O)O)C2

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.36
TSHR P16473 2/20 0.36
LMNA P02545 2/20 0.36
USP2 O75604 1/20 0.36
CYP1A2 P05177 1/20 0.36
BLM P54132 1/20 0.36
CACNA2D1 P54289 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
KMT2A Q03164 2/20 0.34
HPGD P15428 1/20 0.32
KCNA3 P22001 1/20 0.32
CD69 Q07108 1/20 0.31
CYP3A4 P08684 1/20 0.31
CYP2D6 P10635 1/20 0.31
HTR1A P08908 1/20 0.31
HTR1B P28222 1/20 0.31
HTR2A P28223 1/20 0.31
HTR2C P28335 1/20 0.31
HTR7 P34969 1/20 0.31
HTR6 P50406 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6818210 0.82 LMNA (0.39) ALDH1A1TSHRLMNAUSP2CYP1A2
SCHEMBL14459076 0.81 ALDH1A1 (0.40) ALDH1A1TSHRLMNAUSP2CYP1A2
SCHEMBL6818094 0.81 USP2 (0.40) ALDH1A1TSHRLMNAUSP2CYP1A2
SCHEMBL6813335 0.81 HTR1A (0.48) ALDH1A1TSHRLMNAUSP2CYP1A2
SCHEMBL6817221 0.80 ALDH1A1 (0.39) ALDH1A1TSHRLMNAUSP2CYP1A2
SCHEMBL6813555 0.80 USP2 (0.39) ALDH1A1TSHRLMNAUSP2CYP1A2
SCHEMBL6813724 0.80 AKR1B1 (0.44) ALDH1A1TSHRLMNAUSP2CYP1A2
SCHEMBL6817613 0.80 USP2 (0.39) ALDH1A1TSHRLMNAUSP2CYP1A2
SCHEMBL6813480 0.80 TRPA1 (0.39) ALDH1A1TSHRLMNAUSP2CYP1A2
SCHEMBL6818043 0.79 ALDH1A1 (0.39) ALDH1A1TSHRLMNAUSP2CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1180094-B1 FUSED POLYCYCLIC AMINO ACIDS AS PHARMACEUTICAL AGENTS WARNER LAMBERT CO (US) 2004-07-28 EP claimed
EP-1180094-A1 FUSED POLYCYCLIC AMINO ACIDS AS PHARMACEUTICAL AGENTS WARNER-LAMBERT COMPANY (US) 2002-02-20 EP claimed
WO-2000073259-A1 FUSED POLYCYCLIC AMINO ACIDS AS PHARMACEUTICAL AGENTS WARNER-LAMBERT COMPANY (US) 2000-12-07 WO claimed
EP-1180094-B1 FUSED POLYCYCLIC AMINO ACIDS AS PHARMACEUTICAL AGENTS WARNER LAMBERT CO (US) 2004-07-28 EP disclosed
EP-1180094-A1 FUSED POLYCYCLIC AMINO ACIDS AS PHARMACEUTICAL AGENTS WARNER-LAMBERT COMPANY (US) 2002-02-20 EP disclosed
WO-2000073259-A1 FUSED POLYCYCLIC AMINO ACIDS AS PHARMACEUTICAL AGENTS WARNER-LAMBERT COMPANY (US) 2000-12-07 WO disclosed