Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL9 | O00512 | 1/20 | 0.36 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.32 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.32 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 2/20 | 0.30 |
| ▸ | PDE4A | P27815 | 1/20 | 0.30 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6813708 | 0.74 | ALDH1A1 (0.34) | BCL9CTNNB1KDM4EALDH1A1GLA | |
| SCHEMBL7169094 | 0.68 | TP53 (0.40) | ALDH1A1GAAKMT2AMAPTMEN1 | |
| SCHEMBL6814026 | 0.65 | NOD1 (0.41) | GAAKMT2AMAPT | |
| SCHEMBL3639828 | 0.62 | NR1H2 (0.46) | KDM4EALDH1A1GAAKMT2AMAPT | |
| SCHEMBL3448269 | 0.62 | RBP4 (0.36) | ALDH1A1KMT2A | |
| SCHEMBL11023644 | 0.62 | BCL9 (0.70) | BCL9CTNNB1KDM4EALDH1A1GLA | |
| SCHEMBL3686615 | 0.61 | ATM (0.60) | BCL9CTNNB1KDM4EALDH1A1GLA | |
| SCHEMBL28518145 | 0.61 | KMT2A (0.49) | BCL9CTNNB1KDM4EALDH1A1GLA | |
| SCHEMBL27805290 | 0.61 | MAOB (0.49) | BCL9CTNNB1KDM4EALDH1A1GLA | |
| SCHEMBL28611141 | 0.60 | PDGFRB (0.52) | BCL9CTNNB1KDM4EALDH1A1GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6825225-B2 | useful against a number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiply-resistant staphylococci and streptococci, anaerobic organisms such as bacteroides and clostridia species, and acid-fast organisms | PHARMACIA & UPJOHN COMPANY | 2004-11-30 | — | — | US | disclosed |
| US-20040116413-A1 | Novel bicyclic isoxazolinones as antibacterial agents | PHARMACIA & UPJOHN COMPANY | 2004-06-17 | — | — | US | disclosed |