SCHEMBL6814751

SCHEMBL6814751

CNc1nc(NC)c2nc(C)c(C)nc2n1

nearest known ligand 0.36

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TRIM58 Q8NG06 1/20 0.31
YTHDC1 Q96MU7 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29515444 0.74 TRIM58 (0.37) TRIM58YTHDC1
SCHEMBL6819013 0.70 NOS1 (0.56) TRIM58YTHDC1
SCHEMBL22281770 0.69 TRIM58 (0.34) TRIM58
SCHEMBL6811045 0.68 NOS1 (0.41) TRIM58
SCHEMBL6814243 0.66 ADORA1 (0.48)
SCHEMBL6815719 0.66 CYP1A2 (0.43) TRIM58
SCHEMBL11916258 0.64 TRIM58 (0.31) TRIM58
SCHEMBL10485343 0.62 TRIM58 (0.36) TRIM58
SCHEMBL33146 0.61 PDE4A (0.48)
SCHEMBL13239906 0.61 PDE4A (0.34)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1144412-B1 IMMUNOSUPPRESSIVE EFFECTS OF PTERIDINE DERIVATIVES 4 AZA BIOSCIENCE NV (BE) 2004-09-29 EP claimed