Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 1/20 | 0.56 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.49 |
| ▸ | TRIM58 | Q8NG06 | 1/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 9/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | DHFR | P00374 | 1/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.45 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.42 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.42 |
| ▸ | YTHDF2 | Q9Y5A9 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6816554 | 0.87 | NOS1 (0.50) | NOS1NUDT1ADORA1ADORA2ADHFR | |
| SCHEMBL10456274 | 0.86 | NOS1 (0.43) | NOS1NUDT1TRIM58ADORA1ADORA2A | |
| SCHEMBL6811045 | 0.84 | NOS1 (0.41) | NOS1NUDT1TRIM58ADORA1ADORA2A | |
| SCHEMBL6811031 | 0.83 | PIK3CG (0.64) | NOS1ADORA1ADORA2ATDP1DHFR | |
| SCHEMBL6814243 | 0.82 | ADORA1 (0.48) | NOS1ADORA1ADORA2ATDP1DHFR | |
| SCHEMBL6811076 | 0.80 | NUDT1 (0.45) | NOS1NUDT1ADORA1ADORA2ATDP1 | |
| SCHEMBL6811620 | 0.80 | NUDT1 (0.45) | NOS1NUDT1ADORA1ADORA2ATDP1 | |
| SCHEMBL6815719 | 0.79 | CYP1A2 (0.43) | NOS1TRIM58TDP1ALDH1A1KDM4E | |
| SCHEMBL11417487 | 0.75 | NUDT1 (0.57) | NUDT1TRIM58ADORA1ADORA2ATDP1 | |
| SCHEMBL6253328 | 0.74 | ALDH1A1 (0.68) | NOS1NUDT1ADORA2ATDP1DHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1144412-B1 | IMMUNOSUPPRESSIVE EFFECTS OF PTERIDINE DERIVATIVES | 4 AZA BIOSCIENCE NV (BE) | 2004-09-29 | — | — | EP | claimed |