SCHEMBL6817851

SCHEMBL6817851

N#Cc1ccc(NC(=O)c2onc3cc(NS(=O)(=O)Cc4ccccc4)ccc23)c(C(=O)O)c1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IMPDH2 P12268 1/20 0.41
PTPN2 P17706 1/20 0.40
PTPN1 P18031 1/20 0.40
PTPN5 P54829 1/20 0.40
ALB P02768 1/20 0.40
NAMPT P43490 2/20 0.39
ACLY P53396 1/20 0.38
MCL1 Q07820 3/20 0.36
HDAC1 Q13547 1/20 0.36
MAP1LC3B Q9GZQ8 1/20 0.36
MAP1LC3A Q9H492 1/20 0.36
RORC P51449 1/20 0.36
CDK2 P24941 1/20 0.36
HPGD P15428 1/20 0.36
GPR27 Q9NS67 2/20 0.35
AURKA O14965 1/20 0.35
AURKB Q96GD4 1/20 0.35
AVPR2 P30518 1/20 0.35
CCR2 P41597 1/20 0.35
HTT P42858 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6815109 0.93 ALB (0.40) IMPDH2PTPN2PTPN1PTPN5ALB
SCHEMBL6818701 0.87 ALB (0.42) ALBMCL1GPR27AVPR2
SCHEMBL6834174 0.86 IMPDH2 (0.41) IMPDH2PTPN2PTPN1PTPN5ALB
SCHEMBL6833770 0.85 PTPN2 (0.40) IMPDH2PTPN2PTPN1PTPN5ALB
SCHEMBL6818221 0.81 ALB (0.44) ALBCDK2HTT
SCHEMBL6814368 0.81 GPR27 (0.46) PTPN2PTPN1PTPN5ALBMCL1
SCHEMBL6818947 0.80 ALB (0.42) ALBMCL1GPR27AVPR2
SCHEMBL6818988 0.79 LMNA (0.49) NAMPTMCL1RORCAURKAAURKB
SCHEMBL6818795 0.79 CA12 (0.43) ALB
SCHEMBL6818920 0.79 ALB (0.42) ALBCDK2CCR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004018428-A1 ANTIBACTERIAL BENZOIC ACID DERIVATIVES PHARMACIA & UPJOHN COMPANY LLC (US) 2004-03-04 WO disclosed