SCHEMBL6833770

SCHEMBL6833770

N#Cc1ccc(NC(=O)c2noc3ccc(NS(=O)(=O)Cc4ccccc4)cc23)c(C(=O)O)c1

nearest known ligand 0.40

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
PTPN2 P17706 1/20 0.40
PTPN1 P18031 1/20 0.40
PTPN5 P54829 1/20 0.40
ALB P02768 1/20 0.40
IMPDH2 P12268 1/20 0.39
HIF1A Q16665 7/20 0.39
ACLY P53396 1/20 0.38
CDK2 P24941 1/20 0.38
NAMPT P43490 1/20 0.37
CCR2 P41597 1/20 0.37
MCL1 Q07820 2/20 0.36
HDAC1 Q13547 1/20 0.36
BRD4 O60885 1/20 0.36
MAP1LC3B Q9GZQ8 1/20 0.36
MAP1LC3A Q9H492 1/20 0.36
HPGD P15428 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6834174 0.93 IMPDH2 (0.41) PTPN2PTPN1PTPN5ALBIMPDH2
SCHEMBL6835759 0.88 GPR27 (0.46) PTPN2PTPN1PTPN5ALBHIF1A
SCHEMBL6834064 0.87 ALB (0.42) ALBHIF1AMCL1
SCHEMBL6815109 0.86 ALB (0.40) PTPN2PTPN1PTPN5ALBIMPDH2
SCHEMBL6834208 0.86 LMNA (0.49) HIF1ACDK2MCL1HPGD
SCHEMBL6833074 0.85 ALB (0.41) ALBHIF1ACDK2MCL1
SCHEMBL6817851 0.85 IMPDH2 (0.41) PTPN2PTPN1PTPN5ALBIMPDH2
SCHEMBL6713561 0.84 BRD4 (0.38) PTPN2PTPN1PTPN5IMPDH2HIF1A
SCHEMBL6834155 0.84 F2 (0.50) ALBHIF1A
SCHEMBL6708665 0.84 IMPDH2 (0.35) PTPN2PTPN1PTPN5IMPDH2HIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040110802-A1 Antibacterial benzoic acid derivatives PHARMACIA & UPJOHN COMPANY 2004-06-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040110802-A1 Antibacterial benzoic acid derivatives GABRD, GABBR1, GABRA1 PTPN2 3592/4885PTPN1 3166/4885PTPN5 2898/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.