Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6822290 | 1.00 | ALDH1A1 (0.40) | ALDH1A1CYP2C19CYP1A2CYP3A4TSHR | |
| SCHEMBL7135374 | 0.87 | ALDH1A1 (0.39) | ALDH1A1CYP2C19CYP1A2CYP3A4TSHR | |
| SCHEMBL4989211 | 0.80 | CHRNB2 (0.33) | ALDH1A1CYP2C19CYP1A2CYP3A4SMN1; SMN2 | |
| SCHEMBL23583803 | 0.79 | CHRM2 (0.37) | KMT2AMEN1NFKB1NFKB2RELA | |
| SCHEMBL2134574 | 0.79 | CHRM2 (0.37) | KMT2AMEN1NFKB1NFKB2RELA | |
| SCHEMBL6824552 | 0.78 | MAPK1 (0.36) | ALDH1A1SMN1; SMN2KMT2AMEN1PKM | |
| SCHEMBL4995377 | 0.73 | RAB9A (0.34) | ALDH1A1SMN1; SMN2LMNAKMT2ANPSR1 | |
| SCHEMBL1100523 | 0.70 | GAA (0.38) | ALDH1A1CYP2C19CYP1A2CYP3A4TSHR | |
| SCHEMBL11582658 | 0.66 | LMNA (0.46) | ALDH1A1CYP2C19CYP1A2CYP3A4TSHR | |
| SCHEMBL7052178 | 0.66 | GAA (0.42) | ALDH1A1TSHRSMN1; SMN2GAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040167351-A1 | Method for preparing (1R,4S)-2-azabicyclo[2.2.1]hept-5-ene-3-one derivatives | BERNEGGER-EGLI CHRISTINE (CH) | 2004-08-26 | — | — | US | claimed |
| US-6780634-B1 | Method for producing (1R,4S)-2-azabicyclo[2.2.1]-hept-5-en-3-on derivatives | LONZA AG (CH) | 2004-08-24 | — | — | US | claimed |
| EP-1095160-B1 | METHOD FOR PRODUCING (1R,4S)-2-AZABICYCLO 2.2.1 HEPT-5-EN-3-ON DERIVATIVES. | LONZA AG (CH) | 2004-01-28 | — | — | EP | claimed |
| US-20040167351-A1 | Method for preparing (1R,4S)-2-azabicyclo[2.2.1]hept-5-ene-3-one derivatives | BERNEGGER-EGLI CHRISTINE (CH) | 2004-08-26 | — | — | US | disclosed |
| US-6780634-B1 | Method for producing (1R,4S)-2-azabicyclo[2.2.1]-hept-5-en-3-on derivatives | LONZA AG (CH) | 2004-08-24 | — | — | US | disclosed |
| EP-1095160-B1 | METHOD FOR PRODUCING (1R,4S)-2-AZABICYCLO 2.2.1 HEPT-5-EN-3-ON DERIVATIVES. | LONZA AG (CH) | 2004-01-28 | — | — | EP | disclosed |
| EP-1095160-A1 | METHOD FOR PRODUCING (1R,4S)-2-AZABICYCLO 2.2.1 HEPT-5-EN-3-ON DERIVATIVES. | Lonza AG (CH) | 2001-05-02 | — | — | EP | disclosed |
| WO-2000003032-A1 | METHOD FOR PRODUCING (1R,4S)-2-AZABICYLCO[2.2.1]HEPT-5-EN-3-ON DERIVATIVES | LONZA AG (CH) | 2000-01-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040167351-A1 | Method for preparing (1R,4S)-2-azabicyclo[2.2.1]hept-5-ene-3-one derivatives | APEH, CYP51A1, CYP8B1 | ALDH1A1 212/4885CYP2C19 195/4885CYP1A2 26/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.