Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 6/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 1.00 |
| ▸ | CASP6 | P55212 | 1/20 | 1.00 |
| ▸ | CHD1L | Q86WJ1 | 1/20 | 0.76 |
| ▸ | PARP9 | Q8IXQ6 | 1/20 | 0.76 |
| ▸ | MEN1 | O00255 | 2/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.67 |
| ▸ | HPGD | P15428 | 5/20 | 0.67 |
| ▸ | LMNA | P02545 | 2/20 | 0.67 |
| ▸ | FLT3 | P36888 | 3/20 | 0.62 |
| ▸ | RAB9A | P51151 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | FABP4 | P15090 | 2/20 | 0.58 |
| ▸ | FABP5 | Q01469 | 2/20 | 0.58 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20353975 | 0.87 | POLB (0.78) | POLBTDP1CASP6CHD1LPARP9 | |
| SCHEMBL29403771 | 0.82 | ALDH1A1 (0.69) | POLBTDP1CASP6MEN1KMT2A | |
| SCHEMBL21571475 | 0.80 | POLB (0.67) | POLBTDP1CASP6CHD1LPARP9 | |
| SCHEMBL5461038 | 0.79 | FLT3 (0.70) | POLBTDP1CASP6MEN1KMT2A | |
| SCHEMBL8288845 | 0.79 | FLT3 (0.97) | POLBTDP1CASP6MEN1KMT2A | |
| SCHEMBL5455726 | 0.79 | FLT3 (0.97) | POLBTDP1CASP6MEN1KMT2A | |
| SCHEMBL21571479 | 0.78 | POLB (0.64) | POLBTDP1CASP6CHD1LPARP9 | |
| SCHEMBL8288684 | 0.78 | FLT3 (0.90) | POLBTDP1CASP6MEN1KMT2A | |
| SCHEMBL3126680 | 0.78 | FLT3 (0.90) | POLBTDP1CASP6MEN1KMT2A | |
| SCHEMBL8290415 | 0.78 | FLT3 (0.90) | POLBTDP1CASP6MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110275584-A1 | PREVENTION AND TREATMENT OF INFLAMMATION-INDUCED AND/OR IMMUNE-MEDIATED BONE LOSS | ONEPHARM RESEARCH AND DEVELOPMENT GMBH (AT) | 2011-11-10 | — | — | US | disclosed |
| US-20110275584-A1 | PREVENTION AND TREATMENT OF INFLAMMATION-INDUCED AND/OR IMMUNE-MEDIATED BONE LOSS | ONEPHARM RESEARCH AND DEVELOPMENT GMBH (AT) | 2011-11-10 | — | — | US | disclosed |
| US-20100087413-A1 | Prevention and treatment of inflammation-induced and/or immune-mediated bone loss | ONEPHARM RESEARCH AND DEVELOPMENT GMBH (AT) | 2010-04-08 | — | — | US | disclosed |
| US-20100087413-A1 | Prevention and treatment of inflammation-induced and/or immune-mediated bone loss | ONEPHARM RESEARCH AND DEVELOPMENT GMBH (AT) | 2010-04-08 | — | — | US | disclosed |
| US-20080153791-A1 | 11Beta -Hydroxysteroid Dehydrogenases | ONPHARM GMBH (CH) | 2008-06-26 | — | — | US | disclosed |
| US-20080153791-A1 | 11Beta -Hydroxysteroid Dehydrogenases | ONPHARM GMBH (CH) | 2008-06-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080153791-A1 | 11Beta -Hydroxysteroid Dehydrogenases | HSD11B1, HSD11B2, HSD17B1 | POLB 1443/4885TDP1 1294/4885CASP6 3420/4885 |
| US-20110275584-A1 | PREVENTION AND TREATMENT OF INFLAMMATION-INDUCED AND/OR IMMUNE-MEDIATED BONE LOSS | MMP1, MMP11, HSD11B2 | POLB 3117/4885TDP1 2241/4885CASP6 673/4885 |
| US-20100087413-A1 | Prevention and treatment of inflammation-induced and/or immune-mediated bone loss | MMP1, HSD11B1, HSD11B2 | POLB 3035/4885TDP1 2161/4885CASP6 749/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.