Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRIM58 | Q8NG06 | 5/20 | 0.37 |
| ▸ | PAK4 | O96013 | 3/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.33 |
| ▸ | BRAF | P15056 | 2/20 | 0.33 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.33 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MERTK | Q12866 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6816711 | 0.91 | AURKA (0.42) | AURKASRCGSK3BNPY5RSOS1 | |
| SCHEMBL6820499 | 0.87 | TRIM58 (0.37) | TRIM58PAK4AURKASRCGSK3B | |
| SCHEMBL6819632 | 0.85 | ULK1 (0.38) | TRIM58PAK4NPY5RSOS1 | |
| SCHEMBL3767605 | 0.82 | TRIM58 (0.39) | TRIM58PAK4AURKASRCGSK3B | |
| SCHEMBL6823211 | 0.75 | ULK1 (0.46) | AURKASRCGSK3BNPY5RSOS1 | |
| SCHEMBL6820543 | 0.73 | NTRK1 (0.39) | PAK4SRCGSK3B | |
| SCHEMBL6823194 | 0.73 | NPY5R (0.46) | AURKASRCGSK3BNPY5RSOS1 | |
| SCHEMBL7151882 | 0.73 | AURKA (0.59) | AURKASRCGSK3BNPY5RMERTK | |
| SCHEMBL6820558 | 0.73 | PDE5A (0.40) | AURKASRCGSK3BNPY5RSOS1 | |
| SCHEMBL6820537 | 0.73 | ULK1 (0.35) | PAK4NPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004037814-A1 | INDAZOLINONE COMPOSITIONS USEFUL AS KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2004-05-06 | — | — | WO | disclosed |