Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27861942 | 0.83 | SMN1; SMN2 (0.41) | SMN1; SMN2LMNAPOLBALDH1A1KMT2A | |
| SCHEMBL6717843 | 0.78 | L3MBTL1 (0.44) | KMT2AL3MBTL1 | |
| SCHEMBL10792890 | 0.76 | ALDH1A1 (0.34) | SMN1; SMN2ALDH1A1KMT2AMAPTNPSR1 | |
| SCHEMBL6209743 | 0.74 | SMN1; SMN2 (0.43) | SMN1; SMN2LMNAPOLBALDH1A1KMT2A | |
| SCHEMBL6209753 | 0.74 | SMN1; SMN2 (0.43) | SMN1; SMN2LMNAPOLBALDH1A1KMT2A | |
| SCHEMBL4309286 | 0.74 | GRIN2B (0.40) | SMN1; SMN2HPGD | |
| SCHEMBL4437296 | 0.74 | GRIN2B (0.40) | SMN1; SMN2HPGD | |
| SCHEMBL692636 | 0.74 | GRIN2B (0.40) | SMN1; SMN2HPGD | |
| SCHEMBL29937233 | 0.73 | SMN1; SMN2 (0.42) | SMN1; SMN2LMNAPOLBALDH1A1KMT2A | |
| SCHEMBL4725898 | 0.72 | POLB (0.55) | SMN1; SMN2LMNAPOLBALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004043366-A2 | SULFONAMIDES | SMITHKLINE BEECHAM CORPORATION (US) | 2004-05-27 | — | — | WO | disclosed |