Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 1/20 | 0.40 |
| ▸ | SOS1 | Q07889 | 4/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 4/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | XBP1 | P17861 | 2/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6823211 | 0.82 | ULK1 (0.46) | SOS1NPY5RAURKASRCGSK3B | |
| SCHEMBL3761974 | 0.81 | PDE5A (0.41) | PDE5ASOS1NPY5RMAPK1MAPT | |
| SCHEMBL6816711 | 0.81 | AURKA (0.42) | SOS1NPY5RKMT2AAURKASRC | |
| SCHEMBL6823194 | 0.81 | NPY5R (0.46) | PDE5ASOS1NPY5RAURKASRC | |
| SCHEMBL6819632 | 0.74 | ULK1 (0.38) | SOS1NPY5RULK1 | |
| SCHEMBL6820504 | 0.73 | TRIM58 (0.37) | SOS1NPY5RMAPTAURKASRC | |
| SCHEMBL6820499 | 0.73 | TRIM58 (0.37) | SOS1NPY5RMAPTAURKASRC | |
| SCHEMBL6819621 | 0.72 | NTRK1 (0.39) | SOS1NPY5RULK1 | |
| SCHEMBL6820543 | 0.72 | NTRK1 (0.39) | SRCGSK3BULK1 | |
| SCHEMBL6820537 | 0.72 | ULK1 (0.35) | NPY5RULK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004037814-A1 | INDAZOLINONE COMPOSITIONS USEFUL AS KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2004-05-06 | — | — | WO | disclosed |