Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 9/20 | 1.00 |
| ▸ | HTR1A | P08908 | 7/20 | 0.71 |
| ▸ | HTR2A | P28223 | 2/20 | 0.71 |
| ▸ | HTR2C | P28335 | 2/20 | 0.65 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | THPO | P40225 | 1/20 | 0.56 |
| ▸ | MTOR | P42345 | 1/20 | 0.56 |
| ▸ | BLM | P54132 | 1/20 | 0.56 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6825754 | 0.81 | DRD2 (1.00) | DRD2HTR1AHTR2A | |
| SCHEMBL10392901 | 0.81 | DRD2 (0.67) | DRD2HTR1AHTR2AHTR2CSIGMAR1 | |
| SCHEMBL8947948 | 0.79 | HTR1A (1.00) | DRD2HTR1AHTR2AHTR2CSIGMAR1 | |
| SCHEMBL6820627 | 0.78 | DRD2 (1.00) | DRD2HTR1AHTR2AHTR2CSIGMAR1 | |
| SCHEMBL11465528 | 0.78 | SIGMAR1 (0.76) | DRD2HTR1AHTR2AHTR2CSIGMAR1 | |
| SCHEMBL8948129 | 0.78 | HTR1A (0.70) | DRD2HTR1AHTR2AHTR2CSIGMAR1 | |
| SCHEMBL9378627 | 0.77 | SIGMAR1 (1.00) | DRD2HTR1AHTR2CSIGMAR1ALDH1A1 | |
| SCHEMBL1253143 | 0.76 | SIGMAR1 (0.69) | DRD2HTR1ASIGMAR1ALDH1A1CYP1A2 | |
| SCHEMBL8785701 | 0.75 | HTR1A (1.00) | DRD2HTR1AHTR2AHTR2CSIGMAR1 | |
| SCHEMBL9659923 | 0.74 | HTR1A (0.65) | DRD2HTR1AHTR2AHTR2CSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004033426-A2 | HETEROARYL PROPYL-PIPERAZINES AND HETEROARYL PROPYL-PIPERIDINES SERVING AS DOPAMINERGIC AND SEROTONINERGIC AGENTS | PROTEOSYS AG (DE) | 2004-04-22 | — | — | WO | disclosed |