Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 8/20 | 0.70 |
| ▸ | HTR2C | P28335 | 3/20 | 0.70 |
| ▸ | DRD2 | P14416 | 4/20 | 0.64 |
| ▸ | HTR2A | P28223 | 2/20 | 0.63 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.62 |
| ▸ | HTR7 | P34969 | 5/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | THPO | P40225 | 1/20 | 0.52 |
| ▸ | MTOR | P42345 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10392901 | 0.97 | DRD2 (0.67) | HTR1AHTR2CDRD2HTR2ASIGMAR1 | |
| SCHEMBL10394028 | 0.83 | DRD2 (0.62) | HTR1AHTR2CDRD2HTR2ASIGMAR1 | |
| SCHEMBL8947948 | 0.82 | HTR1A (1.00) | HTR1AHTR2CDRD2HTR2ASIGMAR1 | |
| Hydrochloric Acid SCHEMBL7095759 | 0.80 | HTR1A (0.54) | HTR1AHTR2CDRD2HTR2ASIGMAR1 | |
| SCHEMBL10393591 | 0.79 | HTR1A (0.59) | HTR1AHTR2CDRD2HTR2ASIGMAR1 | |
| SCHEMBL10394830 | 0.79 | HTR1A (0.65) | HTR1AHTR2CDRD2HTR2ASIGMAR1 | |
| SCHEMBL6820733 | 0.78 | DRD2 (1.00) | HTR1AHTR2CDRD2HTR2ASIGMAR1 | |
| SCHEMBL9378627 | 0.78 | SIGMAR1 (1.00) | HTR1AHTR2CDRD2SIGMAR1HTR7 | |
| SCHEMBL4892696 | 0.77 | HTR1A (0.64) | HTR1AHTR2CDRD2HTR2AHTR7 | |
| SCHEMBL9595103 | 0.77 | HTR1A (0.71) | HTR1AHTR2CDRD2HTR2ASIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0478446-A1 | Heterocyclic alkylamines, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1992-04-01 | — | — | EP | claimed |
| US-5534517-A | (Aryl(alkyl)carbonyl)-heterocyclic compounds and their use in the treatment of anxiety and depression | ADIR ET COMPAGNIE (FR) | 1996-07-09 | — | — | US | disclosed |
| US-5387586-A | Analgesics, nervous system disorders | ADIR ET COMPAGNIE (FR) | 1995-02-07 | — | — | US | disclosed |
| EP-0613898-A1 | Aryl or arylalkyl-carbonyl heterocyclic derivatives, processes for their preparation and compositions containing them | ADIR ET COMPAGNIE (FR) | 1994-09-07 | — | — | EP | disclosed |