Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.44 |
| ▸ | RAB9A | P51151 | 7/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.41 |
| ▸ | NPC1 | O15118 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 8/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | LATS1 | O95835 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6821893 | 0.78 | ALDH1A1 (0.37) | ALDH1A1SMN1; SMN2KMT2AMAPTCYP1A2 | |
| SCHEMBL1828996 | 0.77 | KDM4E (0.39) | ALDH1A1SMN1; SMN2KMT2AMAPTHPGD | |
| SCHEMBL18065068 | 0.75 | TRPM8 (0.36) | — | |
| SCHEMBL1830315 | 0.74 | KCNN4 (0.40) | ALDH1A1RAB9ASMN1; SMN2NPC1MEN1 | |
| SCHEMBL23251391 | 0.72 | RECQL (0.61) | RECQLALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL30046046 | 0.72 | RECQL (0.61) | RECQLALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL10896790 | 0.72 | L3MBTL1 (0.39) | RAB9ASMN1; SMN2KMT2AMAPTGAA | |
| SCHEMBL7974226 | 0.71 | KDM4E (0.44) | ALDH1A1RAB9ASMN1; SMN2NPC1MEN1 | |
| SCHEMBL7406367 | 0.70 | MAPT (0.33) | ALDH1A1KMT2AMAPTHTT | |
| SCHEMBL7405033 | 0.70 | KCNN4 (0.36) | MEN1KMT2AHTTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002020512-A9 | IMIDAZOLO-5-YL-2-ANILINO-PYRIMIDINES AS AGENTS FOR THE INHIBITION OF THE CELL PROLIFERATION | ASTRAZENECA AB (SE) | 2004-05-06 | — | — | WO | disclosed |
| EP-1351958-A1 | IMIDAZOLO-5-YL-2-ANILINO-PYRIMIDINES AS AGENTS FOR THE INHIBITION OF THE CELL PROLIFERATION | AstraZeneca AB (SE) | 2003-10-15 | — | — | EP | disclosed |
| WO-2002020512-A1 | IMIDAZOLO-5-YL-2-ANILINO-PYRIMIDINES AS AGENTS FOR THE INHIBITION OF THE CELL PROLIFERATION | ASTRAZENECA AB (SE) | 2002-03-14 | — | — | WO | disclosed |