Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | KCNN4 | O15554 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7405033 | 0.82 | KCNN4 (0.36) | KMT2AHTTKCNN4 | |
| SCHEMBL1828996 | 0.82 | KDM4E (0.39) | MAPTKMT2AALDH1A1 | |
| SCHEMBL6821893 | 0.79 | ALDH1A1 (0.37) | MAPTKMT2AALDH1A1KCNN4 | |
| SCHEMBL1830315 | 0.75 | KCNN4 (0.40) | MAPTKMT2AHTTALDH1A1KCNN4 | |
| SCHEMBL10896790 | 0.73 | L3MBTL1 (0.39) | MAPTKMT2AHTT | |
| SCHEMBL18065068 | 0.71 | TRPM8 (0.36) | KCNN4 | |
| SCHEMBL8370808 | 0.70 | LCK (0.38) | KMT2A | |
| SCHEMBL6821626 | 0.70 | RECQL (0.50) | MAPTKMT2AHTTALDH1A1 | |
| SCHEMBL3827052 | 0.70 | KCNN4 (0.33) | MAPTKMT2AALDH1A1KCNN4 | |
| SCHEMBL7974226 | 0.70 | KDM4E (0.44) | MAPTKMT2AHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0969840-A4 | THROMBIN INHIBITORS | MERCK & CO INC (US) | 2001-02-28 | — | — | EP | disclosed |
| EP-0969840-A1 | THROMBIN INHIBITORS | Merck & Co., Inc. (US) | 2000-01-12 | — | — | EP | disclosed |
| WO-1998042342-A1 | THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 1998-10-01 | — | — | WO | disclosed |