Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.32 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.32 |
| ▸ | GABRP | O00591 | 1/20 | 0.32 |
| ▸ | GABRD | O14764 | 1/20 | 0.32 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.32 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4270430 | 0.78 | MAPT (0.39) | MAPTMEN1CYP1A2POLBCYP2D6 | |
| SCHEMBL22576042 | 0.76 | MAPT (0.38) | MAPTMEN1CYP1A2POLBCYP2D6 | |
| SCHEMBL6828247 | 0.76 | NUDT1 (0.44) | MAPTMEN1CYP1A2POLBCYP2D6 | |
| SCHEMBL4276004 | 0.73 | KMT2A (0.41) | MAPTMEN1CYP1A2POLBCYP2D6 | |
| SCHEMBL401293 | 0.72 | CYP1A2 (0.48) | CYP1A2POLBKMT2ASMN1; SMN2LMNA | |
| SCHEMBL2656280 | 0.71 | KMT2A (0.52) | MAPTKMT2ALMNAALDH1A1MCL1 | |
| SCHEMBL12757466 | 0.71 | LMNA (0.47) | CYP1A2SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL12701526 | 0.71 | PDE2A (0.48) | MAPTMEN1CYP1A2POLBCYP2D6 | |
| SCHEMBL28506559 | 0.70 | CYP1A2 (0.47) | CYP1A2POLBKMT2ASMN1; SMN2LMNA | |
| SCHEMBL11273992 | 0.70 | PARP10 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004111000-A2 | PIPERIDYL DERIVATIVES AND THEIR USE AS TACHYKININ ANTAGONISTS | ASTELLAS PHARMA INC. (JP) | 2004-12-23 | — | — | WO | disclosed |