Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 2/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6825996 | 0.83 | CHRM2 (0.42) | SIGMAR1NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL6820957 | 0.82 | ALDH1A1 (0.46) | NPC1RAB9AALDH1A1CNR2CNR1 | |
| SCHEMBL6826045 | 0.81 | SSTR4 (0.39) | KDM4EALDH1A1CNR2CNR1GAA | |
| SCHEMBL6820484 | 0.78 | SYK (0.39) | SIGMAR1SMN1; SMN2KDM4EALDH1A1DRD4 | |
| SCHEMBL7065633 | 0.78 | SIGMAR1 (0.45) | SIGMAR1SMN1; SMN2LMNAKDM4EALDH1A1 | |
| SCHEMBL6820130 | 0.74 | SYK (0.38) | NPC1RAB9ASMN1; SMN2LMNAKDM4E | |
| SCHEMBL27714486 | 0.71 | SIGMAR1 (0.70) | SIGMAR1SMN1; SMN2KDM4EALDH1A1CHRM2 | |
| SCHEMBL10843601 | 0.71 | SMN1; SMN2 (0.44) | NPC1RAB9ASMN1; SMN2LMNAKDM4E | |
| SCHEMBL25119945 | 0.69 | L3MBTL1 (0.44) | NPC1RAB9ASMN1; SMN2LMNAKDM4E | |
| SCHEMBL6825967 | 0.69 | SYK (0.37) | RAB9ASMN1; SMN2KDM4EALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004099185-A1 | 2-CYANOPYRROLIDINE DERIVATIVES AND THEIR USE AS DPP-IV INHIBITORS | FUJISAWA PHARMACEUTICAL CO. LTD. (JP) | 2004-11-18 | — | — | WO | disclosed |
| WO-2004048352-A2 | 2-CYANOPYRROLIDINES AND THEIR ANALOGUES AS DPP-IV INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-06-10 | — | — | WO | disclosed |