SCHEMBL6826600

SCHEMBL6826600

Nc1nccc(-c2cc(C(=O)c3ccc(O)c(-c4ccnc(N)n4)c3)ccc2O)n1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK1 P06493 10/20 0.53
CDK2 P24941 8/20 0.53
CDK5 Q00535 6/20 0.50
CDK5R1 Q15078 6/20 0.50
KDM4C Q9H3R0 1/20 0.47
PRKACA P17612 5/20 0.45
CCNB2 O95067 4/20 0.45
CCNB1 P14635 4/20 0.45
PRKACG P22612 4/20 0.45
PRKACB P22694 4/20 0.45
GSK3B P49841 4/20 0.45
CCNB3 Q8WWL7 4/20 0.45
CSNK1A1 P48729 2/20 0.45
CSNK1D P48730 2/20 0.45
CSNK1E P49674 2/20 0.45
CSNK1G2 P78368 2/20 0.45
CSNK1G1 Q9HCP0 2/20 0.45
CCNE2 O96020 1/20 0.45
PRKCG P05129 1/20 0.45
PRKCB P05771 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6824620 0.94 CDK1 (0.49) CDK1CDK2CDK5CDK5R1KDM4C
SCHEMBL6915719 0.93 DYRK1A (0.49) CDK1CDK2CDK5CDK5R1KDM4C
SCHEMBL6823684 0.92 CDK2 (0.47) CDK1CDK2CDK5CDK5R1KDM4C
SCHEMBL6920709 0.90 HSP90AA1 (0.49) CDK1CDK2CDK5CDK5R1KDM4C
SCHEMBL7174693 0.88 PRKACA (0.47) CDK1CDK2CDK5CDK5R1KDM4C
SCHEMBL7067140 0.87 CDK2 (0.46) CDK1CDK2CDK5CDK5R1KDM4C
SCHEMBL6826746 0.85 CDK1 (0.44) CDK1CDK2CDK5CDK5R1KDM4C
SCHEMBL5803933 0.81 CDK1 (0.58) CDK1CDK2CDK5CDK5R1KDM4C
SCHEMBL6826566 0.80 CYP2D6 (0.46) CDK1CDK2
SCHEMBL6922661 0.80 CDK2 (0.51) CDK1CDK2GSK3BCSNK1A1CSNK1D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004080979-A1 NOVEL 3-(2-AMINO-4-PYRIMIDINYL)-4-HYDROXYPHENYL KETONE DERIVATIVES LG LIFE SCIENCES LTD. (KR) 2004-09-23 WO disclosed
WO-2004080979-A1 NOVEL 3-(2-AMINO-4-PYRIMIDINYL)-4-HYDROXYPHENYL KETONE DERIVATIVES LG LIFE SCIENCES LTD. (KR) 2004-09-23 WO disclosed
WO-2004080979-A1 NOVEL 3-(2-AMINO-4-PYRIMIDINYL)-4-HYDROXYPHENYL KETONE DERIVATIVES LG LIFE SCIENCES LTD. (KR) 2004-09-23 WO disclosed