Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 7/20 | 0.44 |
| ▸ | CDK2 | P24941 | 7/20 | 0.44 |
| ▸ | JAK2 | O60674 | 8/20 | 0.43 |
| ▸ | CDC7 | O00311 | 2/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.41 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.40 |
| ▸ | COMT | P21964 | 1/20 | 0.39 |
| ▸ | PLK4 | O00444 | 1/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.39 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | PRKCG | P05129 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6826600 | 0.85 | CDK1 (0.53) | CDK1CDK2CCNE1CDK5CDK5R1 | |
| SCHEMBL6824620 | 0.80 | CDK1 (0.49) | CDK1CDK2CCNE1CDK5CDK5R1 | |
| SCHEMBL6915719 | 0.79 | DYRK1A (0.49) | CDK1CDK2JAK2CDC7CCNE1 | |
| SCHEMBL6921150 | 0.79 | CDK1 (0.41) | CDK1CDK2JAK2CDC7DBF4 | |
| SCHEMBL6922661 | 0.78 | CDK2 (0.51) | CDK1CDK2JAK2CDC7CCNE1 | |
| SCHEMBL6917094 | 0.78 | CDK2 (0.42) | CDK1CDK2JAK2CDC7CCNE1 | |
| SCHEMBL6823684 | 0.78 | CDK2 (0.47) | CDK1CDK2JAK2CDC7CCNE1 | |
| SCHEMBL6824115 | 0.78 | CDK1 (0.56) | CDK1CDK2JAK2CDC7ROCK2 | |
| SCHEMBL7067140 | 0.76 | CDK2 (0.46) | CDK1CDK2CDC7CCNE1DBF4 | |
| SCHEMBL6920709 | 0.76 | HSP90AA1 (0.49) | CDK1CDK2JAK2CDC7CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004080979-A1 | NOVEL 3-(2-AMINO-4-PYRIMIDINYL)-4-HYDROXYPHENYL KETONE DERIVATIVES | LG LIFE SCIENCES LTD. (KR) | 2004-09-23 | — | — | WO | disclosed |