SCHEMBL6827428

SCHEMBL6827428

COc1ccccc1-c1cc(-c2ccccc2)cc(=O)n1N

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.62
GLO1 Q04760 2/20 0.43
PTPRC P08575 1/20 0.42
PTPN1 P18031 1/20 0.42
HSP90AA1 P07900 1/20 0.42
DCTPP1 Q9H773 1/20 0.41
STK10 O94804 1/20 0.40
SLK Q9H2G2 1/20 0.40
KDM4E B2RXH2 4/20 0.40
LMNA P02545 2/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
BRD4 O60885 1/20 0.39
ALDH1A1 P00352 1/20 0.39
GAA P10253 1/20 0.39
SLC6A9 P48067 1/20 0.39
MAPT P10636 2/20 0.38
NPC1 O15118 2/20 0.38
RAB9A P51151 2/20 0.38
PKM P14618 1/20 0.38
MEN1 O00255 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6824235 0.82 L3MBTL1 (0.65) L3MBTL1GLO1KDM4EALDH1A1GAA
SCHEMBL6827252 0.78 L3MBTL1 (0.73) L3MBTL1GLO1HSP90AA1KDM4ESMN1; SMN2
SCHEMBL6827397 0.77 L3MBTL1 (0.67) L3MBTL1GLO1HSP90AA1BRD4ALDH1A1
SCHEMBL6827244 0.73 L3MBTL1 (0.81) L3MBTL1GLO1HSP90AA1LMNASMN1; SMN2
SCHEMBL6824832 0.73 L3MBTL1 (0.81) L3MBTL1GLO1HSP90AA1LMNASMN1; SMN2
SCHEMBL28043787 0.72 HTR7 (0.51) L3MBTL1PTPRCPTPN1KDM4ELMNA
SCHEMBL28102075 0.72 HTR7 (0.51) L3MBTL1PTPRCPTPN1KDM4ELMNA
Biphenyl SCHEMBL9989359 0.70 ALDH1A1 (0.56) L3MBTL1PTPRCPTPN1STK10SLK
SCHEMBL24106783 0.69 ALDH1A1 (0.55) L3MBTL1PTPRCPTPN1STK10SLK
Methylamine SCHEMBL28363123 0.69 ALDH1A1 (0.55) L3MBTL1PTPRCPTPN1KDM4ELMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004050624-A1 SUBSTITUTED 1H-PYRIDINE-2-ONE DERIVATIVES C & C RESEARCH LABORATORIES (KR) 2004-06-17 WO claimed
WO-2004050624-A1 SUBSTITUTED 1H-PYRIDINE-2-ONE DERIVATIVES C & C RESEARCH LABORATORIES (KR) 2004-06-17 WO disclosed