SCHEMBL682799

SCHEMBL682799

Cn1c(=O)c2c(ncn2CC(O)CN2CCN(C(=O)c3ccc(F)cc3)CC2)n(C)c1=O

nearest known ligand 0.60

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
RXFP1 Q9HBX9 4/20 0.60
RAB9A P51151 1/20 0.56
SMN1; SMN2 Q16637 4/20 0.55
HTR1A P08908 3/20 0.55
DRD2 P14416 3/20 0.55
LMNA P02545 3/20 0.55
CHRM1 P11229 2/20 0.55
ADRA1D P25100 2/20 0.55
ADRA1A P35348 2/20 0.55
ADRA1B P35368 2/20 0.55
POLB P06746 2/20 0.55
ALDH1A1 P00352 1/20 0.50
GAA P10253 1/20 0.49
TSHR P16473 1/20 0.48
KDM4E B2RXH2 1/20 0.47
HTR7 P34969 1/20 0.47
L3MBTL1 Q9Y468 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL684335 0.91 LMNA (0.60) RXFP1SMN1; SMN2LMNAPOLBALDH1A1
SCHEMBL683968 0.88 RAB9A (0.61) RXFP1RAB9AHTR1ADRD2LMNA
SCHEMBL682800 0.86 RXFP1 (0.63) RXFP1RAB9ASMN1; SMN2HTR1ADRD2
SCHEMBL683624 0.85 RXFP1 (0.58) RXFP1RAB9ASMN1; SMN2HTR1ADRD2
Water SCHEMBL10753533 0.85 RXFP1 (0.58) RXFP1RAB9ASMN1; SMN2HTR1ADRD2
SCHEMBL683586 0.83 ALDH1A1 (0.74) RXFP1SMN1; SMN2LMNAPOLBALDH1A1
SCHEMBL11123833 0.81 LMNA (0.75) RXFP1SMN1; SMN2LMNAPOLBALDH1A1
SCHEMBL19626673 0.79 RAB9A (0.58) RXFP1RAB9ASMN1; SMN2HTR1ADRD2
SCHEMBL10569485 0.78 LMNA (0.67) RXFP1SMN1; SMN2LMNAPOLBALDH1A1
SCHEMBL684000 0.78 SMN1; SMN2 (0.65) RXFP1SMN1; SMN2LMNAPOLBALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110269717-A1 NEUROGENESIS BY MODULATING ANGIOTENSIN BRAINCELLS INC. (US) 2011-11-03 US disclosed
US-20110269717-A1 NEUROGENESIS BY MODULATING ANGIOTENSIN BRAINCELLS INC. (US) 2011-11-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110269717-A1 NEUROGENESIS BY MODULATING ANGIOTENSIN NGF, DCX, BDNF RXFP1 211/4885RAB9A 2603/4885SMN1; SMN2 907/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.