Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | PLK1 | P53350 | 1/20 | 0.38 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.38 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.37 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
| ▸ | FLT4 | P35916 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.37 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.37 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.37 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6828673 | 0.93 | MAPK8 (0.44) | MAPK8CCNA2CDK2KDRPLK1 | |
| SCHEMBL6828736 | 0.85 | MAPK8 (0.46) | MAPK8CCNA2CDK2KDRPLK1 | |
| SCHEMBL6829284 | 0.83 | MAPK8 (0.43) | MAPK8CCNA2CDK2KDRPLK1 | |
| SCHEMBL6134270 | 0.78 | MAPK8 (0.51) | MAPK8CCNA2CDK2KDRPLK1 | |
| SCHEMBL6828465 | 0.77 | HPGD (0.41) | RAB9AHPGDKDM4EALDH1A1 | |
| SCHEMBL6830662 | 0.77 | ADORA3 (0.41) | MAPK1RAB9AHPGDSMN1; SMN2KDM4E | |
| SCHEMBL6828733 | 0.76 | HPGDS (0.47) | DHODHMEN1KMT2AHPGDKDM4E | |
| SCHEMBL8833929 | 0.75 | HPGD (0.55) | CLK4RAB9ATP53HPGDNPC1 | |
| SCHEMBL6829904 | 0.74 | NPC1 (0.39) | MAPK1CNR1CNR2RAB9ATP53 | |
| SCHEMBL6133697 | 0.71 | HSD17B10 (0.46) | MAPK1CNR1CNR2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1441732-A2 | THIAZOLE DERIVATIVE AND PHARMACEUTICAL USE THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-08-04 | — | — | EP | disclosed |
| WO-2003039451-A2 | THIAZOLE PYRIDAZINONES AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-05-15 | — | — | WO | disclosed |