Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | ACR | P10323 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.34 |
| ▸ | XIAP | P98170 | 1/20 | 0.34 |
| ▸ | HPGDS | O60760 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6828733 | 0.86 | HPGDS (0.47) | ADORA3ADORA2AADORA1ALDH1A1HSD17B10 | |
| SCHEMBL6828463 | 0.84 | ADORA3 (0.46) | ADORA3ADORA2AADORA2BADORA1TSHR | |
| SCHEMBL6825993 | 0.83 | ADORA3 (0.45) | ADORA3ADORA2AADORA2BADORA1TSHR | |
| SCHEMBL6133796 | 0.78 | ADORA2A (0.50) | ADORA3ADORA2AADORA2BADORA1TSHR | |
| SCHEMBL6828491 | 0.77 | MAPK8 (0.42) | MAPK1ALDH1A1HPGDSMN1; SMN2RAB9A | |
| SCHEMBL6828465 | 0.76 | HPGD (0.41) | ADORA3ADORA2AADORA1TSHRALDH1A1 | |
| SCHEMBL6828673 | 0.75 | MAPK8 (0.44) | MAPK1ALDH1A1HPGDSMN1; SMN2RAB9A | |
| SCHEMBL6828337 | 0.74 | CHEK1 (0.40) | ADORA3ADORA2AADORA2BADORA1ALDH1A1 | |
| SCHEMBL6828438 | 0.72 | L3MBTL1 (0.43) | TSHRMAPK1HSD17B10SMN1; SMN2 | |
| SCHEMBL6828786 | 0.71 | HPGDS (0.49) | ADORA3ALDH1A1HSD17B10HPGDCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1441732-A2 | THIAZOLE DERIVATIVE AND PHARMACEUTICAL USE THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-08-04 | — | — | EP | disclosed |
| WO-2003039451-A2 | THIAZOLE PYRIDAZINONES AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-05-15 | — | — | WO | disclosed |