Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.39 |
| ▸ | HPGDS | O60760 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | ACACA | Q13085 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | XIAP | P98170 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6828673 | 0.83 | MAPK8 (0.44) | HPGDRAB9AALDH1A1MAPK14KDM4E | |
| SCHEMBL6133155 | 0.78 | CYP1A2 (0.50) | HPGDPTGS1RAB9AADORA2AALDH1A1 | |
| SCHEMBL6828733 | 0.77 | HPGDS (0.47) | HPGDHPGDSADORA3ADORA2AALDH1A1 | |
| SCHEMBL6828491 | 0.77 | MAPK8 (0.42) | HPGDRAB9AALDH1A1KDM4E | |
| SCHEMBL6829190 | 0.77 | HPGD (0.45) | HPGDPTGS1HPGDSRAB9AALDH1A1 | |
| SCHEMBL6830662 | 0.76 | ADORA3 (0.41) | HPGDPTGS1HPGDSRAB9AADORA3 | |
| SCHEMBL12127937 | 0.75 | ALDH1A1 (0.56) | PTGS1RAB9AALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL6828786 | 0.73 | HPGDS (0.49) | HPGDHPGDSRAB9AADORA3ALDH1A1 | |
| SCHEMBL4278083 | 0.73 | ADORA2A (0.47) | RAB9AADORA2AALDH1A1ADORA1 | |
| SCHEMBL3311788 | 0.73 | ALDH1A1 (0.60) | HPGDALDH1A1MAPTHSD17B10TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1441732-A2 | THIAZOLE DERIVATIVE AND PHARMACEUTICAL USE THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-08-04 | — | — | EP | disclosed |
| WO-2003039451-A2 | THIAZOLE PYRIDAZINONES AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-05-15 | — | — | WO | disclosed |