Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | KDM5A | P29375 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 3/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 2/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6829284 | 0.91 | MAPK8 (0.43) | NPC1RAB9ADYRK1AMAPK1DGAT1 | |
| SCHEMBL6828343 | 0.85 | TP53 (0.39) | NPC1RAB9AMAPK1TP53MAPK14 | |
| SCHEMBL6828736 | 0.78 | MAPK8 (0.46) | NPC1RAB9ACNR2MAPK1CNR1 | |
| SCHEMBL6828337 | 0.77 | CHEK1 (0.40) | NPC1RAB9AMAPK14 | |
| SCHEMBL6825993 | 0.77 | ADORA3 (0.45) | NPC1RAB9ATP53 | |
| SCHEMBL6828673 | 0.76 | MAPK8 (0.44) | NPC1RAB9ASMYD3DYRK1AMAPK1 | |
| SCHEMBL6828491 | 0.74 | MAPK8 (0.42) | NPC1RAB9ADYRK1ACNR2MAPK1 | |
| SCHEMBL6828438 | 0.74 | L3MBTL1 (0.43) | MAPK1 | |
| SCHEMBL6133269 | 0.73 | HPGD (0.42) | NPC1RAB9ATDP1SMYD3DPP4 | |
| SCHEMBL6830646 | 0.72 | ADORA2A (0.53) | NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1441732-A2 | THIAZOLE DERIVATIVE AND PHARMACEUTICAL USE THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-08-04 | — | — | EP | disclosed |
| WO-2003039451-A2 | THIAZOLE PYRIDAZINONES AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-05-15 | — | — | WO | disclosed |