Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | CLK1 | P49759 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.44 |
| ▸ | CASR | P41180 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | TERT | O14746 | 2/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.41 |
| ▸ | BCHE | P06276 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6828984 | 0.85 | ALK (0.47) | ALDH1A1NPC1TSHRRAB9ATRPV4 | |
| Hydrochloric Acid SCHEMBL6828816 | 0.85 | ALDH1A1 (0.47) | ALDH1A1NPC1TSHRCLK1RAB9A | |
| SCHEMBL6830910 | 0.84 | ALDH1A1 (0.46) | ALDH1A1TSHRLMNAMAPTKMT2A | |
| Hydrochloric Acid SCHEMBL6828860 | 0.84 | ALDH1A1 (0.47) | ALDH1A1NPC1TSHRCLK1RAB9A | |
| Hydrochloric Acid SCHEMBL6829009 | 0.83 | HPGD (0.43) | ALDH1A1NPC1TRPV4LMNAPTGS2 | |
| SCHEMBL6825783 | 0.82 | ADORA1 (0.56) | ALDH1A1TSHRMEN1MAPTKMT2A | |
| SCHEMBL6828830 | 0.80 | ADORA2A (0.48) | ALDH1A1NPC1TSHRRAB9AMEN1 | |
| SCHEMBL6825903 | 0.79 | HPGD (0.47) | ALDH1A1TRPV4LMNACYP2C19PTGS2 | |
| SCHEMBL6830218 | 0.79 | ALDH1A1 (0.43) | ALDH1A1TSHRLMNAMEN1MAPT | |
| SCHEMBL6830646 | 0.79 | ADORA2A (0.53) | ALDH1A1NPC1RAB9ALMNAGSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1441732-A2 | THIAZOLE DERIVATIVE AND PHARMACEUTICAL USE THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-08-04 | — | — | EP | disclosed |
| WO-2003039451-A2 | THIAZOLE PYRIDAZINONES AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-05-15 | — | — | WO | disclosed |