Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 8/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 9/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 6/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.38 |
| ▸ | XIAP | P98170 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6828434 | 0.90 | HDAC1 (0.44) | ADORA2AADORA1ADORA3HDAC1XIAP | |
| SCHEMBL6828729 | 0.82 | ADORA1 (0.57) | ADORA2AADORA1ADORA3KMT2ASMN1; SMN2 | |
| SCHEMBL6826020 | 0.81 | NPC1 (0.48) | ADORA2AADORA1ADORA3XIAPKMT2A | |
| SCHEMBL6830337 | 0.81 | ADORA2A (0.50) | ADORA2AADORA1ADORA3XIAPKMT2A | |
| SCHEMBL6828972 | 0.80 | TRPV4 (0.47) | ADORA2AADORA1ADORA3KMT2ASMN1; SMN2 | |
| SCHEMBL6828379 | 0.80 | ALK (0.49) | HDAC1 | |
| SCHEMBL6830218 | 0.79 | ALDH1A1 (0.43) | ADORA2AADORA1XIAPKMT2ASMN1; SMN2 | |
| SCHEMBL6828984 | 0.79 | ALK (0.47) | HDAC1KMT2ASMN1; SMN2KDM4EMAPT | |
| SCHEMBL6134793 | 0.79 | ADORA2A (0.45) | ADORA2AADORA1ADORA3XIAPKMT2A | |
| SCHEMBL6828357 | 0.77 | ADORA2A (0.51) | ADORA2AADORA1ADORA3XIAPKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1441732-A2 | THIAZOLE DERIVATIVE AND PHARMACEUTICAL USE THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-08-04 | — | — | EP | disclosed |
| WO-2003039451-A2 | THIAZOLE PYRIDAZINONES AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-05-15 | — | — | WO | disclosed |