Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 12/20 | 0.55 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7085731 | 0.85 | HTR6 (0.53) | HTR6DRD2DRD4CYP2D6 | |
| SCHEMBL6829699 | 0.76 | HTR6 (0.60) | HTR6CHRM1CYP3A4CYP2D6 | |
| SCHEMBL7085263 | 0.74 | SIGMAR1 (0.56) | HTR6DRD2 | |
| SCHEMBL1537822 | 0.72 | HTR6 (0.75) | HTR6CHRM1CYP3A4CYP2D6 | |
| SCHEMBL3561901 | 0.70 | ACLY (0.46) | HTR6CHRM1CA12CA1CA2 | |
| SCHEMBL3563939 | 0.70 | ACLY (0.62) | CA12CA2CA9 | |
| SCHEMBL3223044 | 0.67 | HTR6 (1.00) | HTR6CHRM1CYP3A4CYP2D6 | |
| SCHEMBL3409661 | 0.67 | HTR6 (1.00) | HTR6CHRM1CYP3A4CYP2D6 | |
| Hydrochloric Acid SCHEMBL3219058 | 0.66 | HTR6 (0.98) | HTR6CHRM1CYP3A4CYP2D6 | |
| SCHEMBL4304442 | 0.65 | HTR6 (0.54) | HTR6DRD2CYP3A4CA12CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1343756-A2 | 1-ARYL- OR 1-ALKYLSULFONYL-HETEROCYCLYLBENZAZOLES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | Wyeth (US) | 2003-09-17 | — | — | EP | disclosed |
| WO-2002036562-A2 | 1-ARYL- OR 1-ALKYLSULFONYL-HETEROCYCLYLBENZAZOLES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | WYETH (US) | 2002-05-10 | — | — | WO | disclosed |