Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | BCHE | P06276 | 4/20 | 0.46 |
| ▸ | ACHE | P22303 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30439094 | 0.82 | TDP1 (0.57) | TDP1ATML3MBTL1RAB9AKMT2A | |
| SCHEMBL11212298 | 0.81 | TDP1 (0.61) | TDP1ATML3MBTL1RAB9AKMT2A | |
| Phenyl Dimethylcarbamate SCHEMBL491227 | 0.81 | RAB9A (0.78) | TDP1ATML3MBTL1RAB9AKMT2A | |
| SCHEMBL7194185 | 0.81 | TDP1 (0.61) | TDP1ATML3MBTL1RAB9AKMT2A | |
| SCHEMBL9858698 | 0.79 | L3MBTL1 (0.50) | TDP1ATML3MBTL1RAB9AKMT2A | |
| SCHEMBL12786094 | 0.79 | TDP1 (0.59) | TDP1ATML3MBTL1RAB9AKMT2A | |
| SCHEMBL1423356 | 0.79 | ACHE (0.55) | TDP1ATML3MBTL1KMT2AALDH1A1 | |
| SCHEMBL27806243 | 0.78 | L3MBTL1 (0.49) | TDP1ATML3MBTL1RAB9AKMT2A | |
| SCHEMBL11029662 | 0.78 | TDP1 (0.57) | TDP1ATML3MBTL1RAB9AKMT2A | |
| Phenyl Dimethylcarbamate SCHEMBL27760797 | 0.78 | RAB9A (0.72) | TDP1ATML3MBTL1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6743923-B2 | A BENZYLIDENE DERIVATIVES USED FOR OSTEOCLAST FORMATION INHIBITION, A NITROGEN MONOXIDE PRODUCTION INHIBITION, AND A TRANSCRIPTION FACTOR NF KAPPA B SUPRESSING AGENT | SHIONOGI & CO., LTD. (JP) | 2004-06-01 | — | — | US | disclosed |
| US-20030125364-A1 | Antirheumatic agent | MATSUMOTO SAICHI (JP) | 2003-07-03 | — | — | US | disclosed |
| US-6525081-B1 | Inhibiting osteoclast formation and nitrogen monoxide production; suppressing transcription factor NF kappa B | SHIONOGI & CO., LTD. (JP) | 2003-02-25 | — | — | US | disclosed |
| EP-1026162-A1 | ANTIRHEUMATIC | SHIONOGI & CO., LTD. (JP) | 2000-08-09 | — | — | EP | disclosed |
| EP-0595546-B1 | Benzylidene derivatives | SHIONOGI & CO (JP) | 1996-03-20 | — | — | EP | disclosed |
| US-5418230-A | Antiinflammatory | SHIONOGI & CO., LTD. (JP) | 1995-05-23 | — | — | US | disclosed |
| EP-0595546-A1 | Benzylidene derivatives | SHIONOGI & CO., LTD. (JP) | 1994-05-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030125364-A1 | Antirheumatic agent | IL1A, IL1B, IL17A | TDP1 2154/4885ATM 4884/4885L3MBTL1 4836/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.