Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.44 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.44 |
| ▸ | SCN2A | Q99250 | 3/20 | 0.40 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.38 |
| ▸ | SCN4A | P35499 | 6/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | SCN1A | P35498 | 2/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24823151 | 0.83 | ALDH1A1 (0.51) | ALDH1A1PTPN1KDM4ESMN1; SMN2GAA | |
| SCHEMBL13594738 | 0.82 | PTPN1 (0.61) | ALDH1A1PTPN1KDM4ESCN2ASCN4A | |
| SCHEMBL12772148 | 0.81 | ALDH1A1 (0.36) | ALDH1A1PTPN1KDM4ESMN1; SMN2GAA | |
| SCHEMBL11646260 | 0.79 | GABRA1 (0.52) | ALDH1A1KDM4ESMN1; SMN2GAAGABRA1 | |
| SCHEMBL12843836 | 0.79 | PTPN1 (0.42) | ALDH1A1PTPN1KDM4ESMN1; SMN2GAA | |
| SCHEMBL73389 | 0.79 | ALDH1A1 (0.61) | ALDH1A1KDM4ESMN1; SMN2GAAGABRA1 | |
| SCHEMBL16479215 | 0.79 | ALDH1A1 (0.61) | ALDH1A1KDM4ESMN1; SMN2GAAGABRA1 | |
| SCHEMBL9186079 | 0.79 | ALDH1A1 (0.54) | ALDH1A1KDM4ESMN1; SMN2GAAGABRA1 | |
| SCHEMBL1728866 | 0.78 | PIM1 (0.44) | ALDH1A1PTPN1KDM4ESMN1; SMN2GAA | |
| SCHEMBL11333666 | 0.77 | ALDH1A1 (0.60) | ALDH1A1KDM4ESMN1; SMN2GAAGABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6743923-B2 | A BENZYLIDENE DERIVATIVES USED FOR OSTEOCLAST FORMATION INHIBITION, A NITROGEN MONOXIDE PRODUCTION INHIBITION, AND A TRANSCRIPTION FACTOR NF KAPPA B SUPRESSING AGENT | SHIONOGI & CO., LTD. (JP) | 2004-06-01 | — | — | US | disclosed |
| US-20030125364-A1 | Antirheumatic agent | MATSUMOTO SAICHI (JP) | 2003-07-03 | — | — | US | disclosed |
| US-6525081-B1 | Inhibiting osteoclast formation and nitrogen monoxide production; suppressing transcription factor NF kappa B | SHIONOGI & CO., LTD. (JP) | 2003-02-25 | — | — | US | disclosed |
| EP-1026162-A1 | ANTIRHEUMATIC | SHIONOGI & CO., LTD. (JP) | 2000-08-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030125364-A1 | Antirheumatic agent | IL1A, IL1B, IL17A | ALDH1A1 236/4885PTPN1 2724/4885KDM4E 3480/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.