Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 1/20 | 0.39 |
| ▸ | ACE | P12821 | 1/20 | 0.39 |
| ▸ | CPA1 | P15085 | 1/20 | 0.39 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.39 |
| ▸ | FNTA | P49354 | 3/20 | 0.38 |
| ▸ | FNTB | P49356 | 3/20 | 0.38 |
| ▸ | PGGT1B | P53609 | 3/20 | 0.38 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CLPP | Q16740 | 2/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | NTSR1 | P30989 | 3/20 | 0.35 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6830895 | 0.84 | CASP3 (0.43) | FNTAFNTBPGGT1BKCNA5CLPP | |
| SCHEMBL7418205 | 0.83 | LMNA (0.53) | KMT2ALMNARAB9A | |
| SCHEMBL7201963 | 0.78 | CASP3 (0.48) | MMEACECPA1ACE2PSMB5 | |
| SCHEMBL7201964 | 0.78 | CASP3 (0.48) | MMEACECPA1ACE2PSMB5 | |
| SCHEMBL6830923 | 0.75 | LMNA (0.42) | MMEACECPA1ACE2KMT2A | |
| SCHEMBL6832903 | 0.73 | KCNA5 (0.39) | MMEACECPA1ACE2FNTA | |
| SCHEMBL7361590 | 0.70 | ALDH1A1 (0.50) | MMEACECPA1ACE2FNTA | |
| SCHEMBL8353758 | 0.68 | CASP3 (0.46) | MMEACECPA1ACE2PSMB5 | |
| SCHEMBL9824719 | 0.67 | POLB (0.53) | MMEACECPA1ACE2PSMB5 | |
| SCHEMBL9824722 | 0.67 | POLB (0.53) | MMEACECPA1ACE2PSMB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1480999-A2 | (SUBSTITUTED)ACYL DIPEPTIDYL INHIBITORS OF THE ICE/CED-3 FAMILY OF CYSTEINE PROTEASES | Idun Pharmaceuticals (US) | 2004-12-01 | — | — | EP | disclosed |
| WO-2003072528-A2 | (SUBSTITUTED)ACYL DIPEPTIDYL INHIBITORS OF THE ICE/CED-3 FAMILY OF CYSTEINE PROTEASES | IDUN PHARMACEUTICALS, INC. (US) | 2003-09-04 | — | — | WO | disclosed |