Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 8/20 | 0.43 |
| ▸ | CASP6 | P55212 | 8/20 | 0.43 |
| ▸ | CASP8 | Q14790 | 8/20 | 0.43 |
| ▸ | FNTA | P49354 | 5/20 | 0.40 |
| ▸ | FNTB | P49356 | 5/20 | 0.40 |
| ▸ | PGGT1B | P53609 | 5/20 | 0.40 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.39 |
| ▸ | CLPP | Q16740 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6832902 | 0.84 | MME (0.39) | FNTAFNTBPGGT1BKCNA5CLPP | |
| SCHEMBL7204618 | 0.82 | CASP3 (0.59) | CASP3CASP6CASP8CLPPCASP1 | |
| SCHEMBL6830897 | 0.75 | FNTA (0.40) | CASP3CASP6CASP8FNTAFNTB | |
| SCHEMBL7418205 | 0.74 | LMNA (0.53) | CASP3CASP6CASP8ALDH1A1CASP1 | |
| SCHEMBL14598408 | 0.70 | CASP3 (0.60) | CASP3CASP6CASP8ALDH1A1CASP1 | |
| SCHEMBL5497139 | 0.70 | CASP3 (0.53) | CASP3CASP6CASP8 | |
| SCHEMBL6832903 | 0.69 | KCNA5 (0.39) | FNTAFNTBPGGT1BKCNA5CLPP | |
| SCHEMBL7361590 | 0.68 | ALDH1A1 (0.50) | FNTAFNTBALDH1A1MMP1 | |
| SCHEMBL7201964 | 0.66 | CASP3 (0.48) | CASP3CASP6CASP8CLPPCASP1 | |
| SCHEMBL7201963 | 0.66 | CASP3 (0.48) | CASP3CASP6CASP8CLPPCASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1480999-A2 | (SUBSTITUTED)ACYL DIPEPTIDYL INHIBITORS OF THE ICE/CED-3 FAMILY OF CYSTEINE PROTEASES | Idun Pharmaceuticals (US) | 2004-12-01 | — | — | EP | disclosed |
| WO-2003072528-A2 | (SUBSTITUTED)ACYL DIPEPTIDYL INHIBITORS OF THE ICE/CED-3 FAMILY OF CYSTEINE PROTEASES | IDUN PHARMACEUTICALS, INC. (US) | 2003-09-04 | — | — | WO | disclosed |