SCHEMBL6833253

SCHEMBL6833253

N#Cc1ccc(NC(=O)c2cncc(-c3cnccn3)c2)c(C(=O)O)c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAK O14976 1/20 0.46
STK16 O75716 1/20 0.46
PIM1 P11309 1/20 0.46
AXL P30530 1/20 0.46
NEK2 P51955 1/20 0.46
STK3 Q13188 1/20 0.46
STK11 Q15831 1/20 0.46
AAK1 Q2M2I8 1/20 0.46
BMP2K Q9NSY1 1/20 0.46
TNIK Q9UKE5 1/20 0.46
KCNH2 Q12809 1/20 0.45
SCN10A Q9Y5Y9 1/20 0.45
PPARG P37231 2/20 0.45
ALB P02768 2/20 0.45
PORCN Q9H237 2/20 0.43
XDH P47989 1/20 0.43
ALDH1A1 P00352 1/20 0.42
KDM4D Q6B0I6 1/20 0.40
KDM4C Q9H3R0 1/20 0.40
GRM5 P41594 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6833241 0.89 MAPK14 (0.47) GAKSTK16PIM1AXLNEK2
SCHEMBL6833755 0.84 KCNH2 (0.55) GAKSTK16PIM1AXLNEK2
SCHEMBL6834140 0.81 SCN10A (0.54) GAKSTK16PIM1AXLNEK2
SCHEMBL6834011 0.80 MEN1 (0.51) PPARGALBALDH1A1KMT2A
SCHEMBL6833179 0.79 ALDH1A1 (0.66) ALBALDH1A1ABL1KMT2A
SCHEMBL6830011 0.79 SERPINE1 (0.49) GAKSTK16PIM1AXLNEK2
SCHEMBL6835718 0.79 SERPINE1 (0.50) GAKSTK16PIM1AXLNEK2
SCHEMBL6833875 0.79 KDM4E (0.52) GAKSTK16PIM1AXLNEK2
SCHEMBL6830649 0.79 KCNH2 (0.54) GAKSTK16PIM1AXLNEK2
SCHEMBL6834158 0.79 XDH (0.54) AAK1KCNH2SCN10AALBXDH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040110802-A1 Antibacterial benzoic acid derivatives PHARMACIA & UPJOHN COMPANY 2004-06-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040110802-A1 Antibacterial benzoic acid derivatives GABRD, GABBR1, GABRA1 GAK 2608/4885STK16 2636/4885PIM1 2201/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.