SCHEMBL6833337

SCHEMBL6833337

N#Cc1ccc(NC(=O)c2cc3cccc(NC(=O)Cc4ccc(C(F)(F)F)cc4)c3[nH]2)c(C(=O)O)c1

nearest known ligand 0.45

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
RXFP1 Q9HBX9 3/20 0.45
NR1H4 Q96RI1 3/20 0.43
PPARG P37231 2/20 0.43
PPARD Q03181 2/20 0.43
PPARA Q07869 2/20 0.43
NLRP3 Q96P20 1/20 0.41
PLK1 P53350 1/20 0.40
CDK2 P24941 1/20 0.40
LMNA P02545 1/20 0.38
PARP14 Q460N5 1/20 0.38
HDAC2 Q92769 1/20 0.38
LRRK2 Q5S007 1/20 0.38
ALB P02768 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6830257 0.94 RXFP1 (0.48) RXFP1NR1H4PPARGPPARDPPARA
SCHEMBL6833683 0.92 NR1H4 (0.48) NR1H4PPARGPPARDPPARANLRP3
SCHEMBL6835671 0.92 LMNA (0.39) RXFP1LMNAPARP14HDAC2ALB
SCHEMBL6834504 0.91 LMNA (0.47) RXFP1LMNAPARP14ALB
SCHEMBL6834072 0.90 ALDH1A1 (0.41) PLK1LMNAPARP14ALB
SCHEMBL6834079 0.90 NHERF1 (0.44) LMNAPARP14ALB
SCHEMBL6833766 0.90 PARP14 (0.43) NR1H4PPARGPPARDPPARALMNA
SCHEMBL6834298 0.88 MEN1 (0.44) NR1H4PPARGPPARDPPARANLRP3
SCHEMBL6834134 0.88 IDO1 (0.43) NR1H4NLRP3LMNAPARP14ALB
SCHEMBL6834350 0.88 ALDH1A1 (0.50) PPARDNLRP3PLK1PARP14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040110802-A1 Antibacterial benzoic acid derivatives PHARMACIA & UPJOHN COMPANY 2004-06-10 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040110802-A1 Antibacterial benzoic acid derivatives GABRD, GABBR1, GABRA1 RXFP1 3523/4885NR1H4 1201/4885PPARG 285/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.