Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | ELANE | P08246 | 4/20 | 0.40 |
| ▸ | F2 | P00734 | 3/20 | 0.38 |
| ▸ | PLAU | P00749 | 3/20 | 0.38 |
| ▸ | CTRB1 | P17538 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6833681 | 0.98 | SMN1; SMN2 (0.44) | SMN1; SMN2MITFALDH1A1LMNACYP1A2 | |
| Nitric Acid SCHEMBL6822404 | 0.86 | SMN1; SMN2 (0.40) | SMN1; SMN2MITFALDH1A1LMNACYP1A2 | |
| SCHEMBL6818214 | 0.84 | SMN1; SMN2 (0.41) | SMN1; SMN2MITFALDH1A1LMNACYP1A2 | |
| SCHEMBL492280 | 0.79 | LMNA (0.63) | SMN1; SMN2MITFALDH1A1LMNACYP1A2 | |
| SCHEMBL8221496 | 0.77 | LMNA (0.41) | SMN1; SMN2MITFALDH1A1LMNACYP1A2 | |
| SCHEMBL6834684 | 0.74 | LMNA (0.41) | ALDH1A1LMNACYP1A2MAPTAKR1C2 | |
| Sulfuric Acid SCHEMBL6819163 | 0.70 | AKR1C2 (0.44) | ALDH1A1LMNACYP1A2MAPTAKR1C3 | |
| SCHEMBL6833135 | 0.70 | KCNK2 (0.40) | ALDH1A1LMNACYP1A2MAPTAKR1C3 | |
| SCHEMBL15898967 | 0.69 | MLYCD (0.50) | ALDH1A1LMNAMAPTMEN1KMT2A | |
| SCHEMBL6830547 | 0.69 | EPHX2 (0.49) | SMN1; SMN2ALDH1A1CYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040110802-A1 | Antibacterial benzoic acid derivatives | PHARMACIA & UPJOHN COMPANY | 2004-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040110802-A1 | Antibacterial benzoic acid derivatives | GABRD, GABBR1, GABRA1 | SMN1; SMN2 2022/4885MITF 2987/4885ALDH1A1 170/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.