Sugi Predict

Sugi Predict / Compounds / SCHEMBL6834540

SCHEMBL6834540

SCHEMBL6834540

NS(=O)(=O)c1cc(F)cc(-c2ncccc2-c2cccc(Cl)c2)c1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CA1 P00915 6/20 0.42
▸ CA2 P00918 6/20 0.42
▸ PTGS2 P35354 4/20 0.41
▸ PTGS1 P23219 3/20 0.41
▸ RORB Q92753 1/20 0.39
▸ NPC1 O15118 1/20 0.39
▸ HPGD P15428 1/20 0.39
▸ HTT P42858 1/20 0.39
▸ CA9 Q16790 2/20 0.38
▸ CA13 Q8N1Q1 1/20 0.38
▸ KDR P35968 1/20 0.38
▸ EPHB4 P54760 1/20 0.38
▸ PTGES2 Q9H7Z7 1/20 0.38
▸ CHRNA7 P36544 1/20 0.38
▸ PDE4A P27815 1/20 0.38
▸ PDE4C Q08493 1/20 0.38
▸ PDE4D Q08499 1/20 0.38
▸ CA12 O43570 1/20 0.38
▸ SCN9A Q15858 1/20 0.37
▸ IKBKB O14920 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6841006 0.91 CA1 (0.41) CA1CA2PTGS2PTGS1CA9
SCHEMBL6834947 0.90 CHRNA7 (0.43) CA1CA2PTGS2PTGS1CA9
SCHEMBL6835388 0.88 PTGS2 (0.49) CA1CA2PTGS2PTGS1CA9
SCHEMBL6835856 0.87 PTGS2 (0.52) CA1CA2PTGS2PTGS1CA9
SCHEMBL6841538 0.86 CA1 (0.45) CA1CA2PTGS2PTGS1CA9
SCHEMBL6837963 0.86 CA1 (0.41) CA1CA2PTGS2PTGS1CA9
SCHEMBL6835085 0.86 CA1 (0.42) CA1CA2PTGS2PTGS1CA9
SCHEMBL6836086 0.86 PTGS1 (0.46) CA1CA2PTGS2PTGS1CA9
SCHEMBL6840518 0.86 CA1 (0.44) CA1CA2PTGS2PTGS1CA9
SCHEMBL6835049 0.84 LMNA (0.42) CA1CA2PTGS2PTGS1CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040138261-A1 Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation PHARMACIA CORPORATION 2004-07-15 — — US disclosed
US-6673818-B2 TREATING CYCLOOXYGENASE-2 MEDIATED DISORDERS, SUCH AS ARTHRITIS, PAIN, FEVER AND CANCER PHARMACIA CORPORATION 2004-01-06 — — US disclosed
US-20030149078-A1 Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation PHARMACIA CORPORATION 2003-08-07 — — US disclosed
US-20030032657-A1 Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation PHARMACIA CORPORATION 2003-02-13 — — US disclosed
EP-1251126-A2 Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation Pharmacia Corporation (US) 2002-10-23 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040138261-A1 Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation FPR1, FPR2, FPR3 CA1 2085/4885CA2 3175/4885PTGS2 10/4885
US-20030149078-A1 Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation FPR1, FPR2, FPR3 CA1 2085/4885CA2 3175/4885PTGS2 10/4885
US-20030032657-A1 Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation FPR1, FPR2, FPR3 CA1 2085/4885CA2 3175/4885PTGS2 10/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.