Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6831721 | 0.92 | MAPT (0.47) | ALDH1A1MAPK1ROCK2ROCK1KMT2A | |
| SCHEMBL6683279 | 0.91 | NPC1 (0.49) | ALDH1A1MAPK1ROCK2ROCK1KMT2A | |
| SCHEMBL6837120 | 0.90 | TP53 (0.47) | ALDH1A1MAPK1ROCK2ROCK1RXFP1 | |
| SCHEMBL6835283 | 0.90 | LMNA (0.47) | ALDH1A1MAPK1ROCK2ROCK1KMT2A | |
| SCHEMBL6835519 | 0.89 | ALDH1A1 (0.44) | ALDH1A1MAPK1ROCK2ROCK1KMT2A | |
| SCHEMBL6831840 | 0.89 | TP53 (0.42) | MAPK1ROCK2ROCK1MAPTLMNA | |
| SCHEMBL6831844 | 0.88 | ALDH1A1 (0.45) | ALDH1A1MAPK1ROCK2ROCK1KMT2A | |
| SCHEMBL6835368 | 0.88 | ALDH1A1 (0.44) | ALDH1A1MAPK1ROCK2ROCK1KMT2A | |
| SCHEMBL6837107 | 0.83 | RXFP1 (0.48) | ALDH1A1MAPK1ROCK2ROCK1RXFP1 | |
| SCHEMBL6668041 | 0.82 | MAPT (0.51) | ALDH1A1MAPK1ROCK2ROCK1RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040043985-A1 | 6,6-Fused heteroaryl derivatives as matrix metalloproteinase inhibitors | HICKS JAMES LESTER (US) | 2004-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040043985-A1 | 6,6-Fused heteroaryl derivatives as matrix metalloproteinase inhibitors | MMP13, MMP26, MMP9 | ALDH1A1 1202/4885MAPK1 857/4885ROCK2 38/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.