Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.35 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KCNQ4 | P56696 | 2/20 | 0.34 |
| ▸ | KCNQ5 | Q9NR82 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6835125 | 0.88 | MKNK2 (0.36) | MKNK2CNR2ALOX15CRHBPCRHR2 | |
| SCHEMBL6831525 | 0.85 | ALDH1A1 (0.42) | MKNK2CNR2ALOX15CRHBPCRHR2 | |
| SCHEMBL7669102 | 0.85 | CRHBP (0.43) | MKNK2CNR2CRHBPCRHR2ALDH1A1 | |
| SCHEMBL6834321 | 0.83 | CNR2 (0.38) | CNR2ALDH1A1LMNAMAPT | |
| SCHEMBL14271848 | 0.82 | APOBEC3A (0.40) | CNR2KDM4EALDH1A1MAPTKCNQ4 | |
| SCHEMBL21868962 | 0.82 | CNR2 (0.36) | MKNK2CNR2ALOX15CRHBPCRHR2 | |
| SCHEMBL3556821 | 0.81 | MEN1 (0.41) | ALOX15KDM4EALDH1A1MAPTKMT2A | |
| SCHEMBL7660400 | 0.79 | RAB9A (0.52) | ALDH1A1LMNAMAPTKMT2ANPC1 | |
| SCHEMBL4544314 | 0.79 | CNR2 (0.39) | CNR2ALOX15ALDH1A1LMNAMAPT | |
| SCHEMBL7057039 | 0.76 | CNR2 (0.46) | CNR2ALDH1A1LMNAKMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7326729-B2 | CXCR1 and CXCR2 chemokine antagonists | SCHERING CORPORATION (US) | 2008-02-05 | — | — | US | disclosed |
| US-20070248594-A1 | CXCR1 AND CXCR2 CHEMOKINE ANTAGONISTS | SCHERING CORPORATION | 2007-10-25 | — | — | US | disclosed |
| US-20040014984-A1 | Process for the preparation of derivatives of 4-amino-3-hydroxypyrrole-2-carboxylic acid | PHARMACIA CORPORATION | 2004-01-22 | — | — | US | disclosed |
| US-6632950-B2 | By reducing the corresponding 4-nitro derivative; useful as monomers for polyamides capable of binding dsDNA (double stranded DNA) and hence in nucleotide sequence recognition | PHARMACIA CORPORATION | 2003-10-14 | — | — | US | disclosed |
| US-6472537-B1 | POLYMERS FROM PRIMARY AMINE AND CARBOXYLIC ACID SUBSTITUTED PYROLE, HYDROXYPYROLE AND IMIDAZOLE MONOMERS AND HAVING 4-AMINOBUTYRIC ACID LINKER FORMING HAIRPIN TURNS AND OPTION-ALLY AMINO ACID RESIDUES; BINDING TO SPECIFIC | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2002-10-29 | — | — | US | disclosed |
| US-20020042522-A1 | Process for the preparation of derivative of 4-amino-3-hydroxypyrrole-2-carboxylic acid | PHARMACIA CORPORATION | 2002-04-11 | — | — | US | disclosed |
| WO-2002004417-A1 | PROCESS FOR THE PREPARATION OF DERIVATIVES OF 4-AMINO-3-HYDROXYPYRROLE-2-CARBOXYLIC ACID | PHARMACIA CORPORAION (US) | 2002-01-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040014984-A1 | Process for the preparation of derivatives of 4-amino-3-hydroxypyrrole-2-carboxylic acid | POLL, LIG4, HPD | MKNK2 2479/4885CNR2 4295/4885ALOX15 4534/4885 |
| US-20070248594-A1 | CXCR1 AND CXCR2 CHEMOKINE ANTAGONISTS | CXCR1, CXCR2, CXCR5 | MKNK2 2161/4885CNR2 176/4885ALOX15 1208/4885 |
| US-20020042522-A1 | Process for the preparation of derivative of 4-amino-3-hydroxypyrrole-2-carboxylic acid | LIG4, POLL, HPD | MKNK2 2498/4885CNR2 4300/4885ALOX15 4545/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.