Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMP | P19971 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TK1 | P04183 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6837969 | 0.90 | TYMP (0.41) | TYMPMAPK1KMT2AHPGDTK1 | |
| SCHEMBL7529481 | 0.85 | HPGD (0.43) | TYMPMAPK1HPGDTK1 | |
| SCHEMBL8645218 | 0.80 | TK1 (0.42) | TYMPMAPK1KMT2AHPGDTK1 | |
| SCHEMBL6837658 | 0.79 | MAPK1 (0.40) | TYMPMAPK1KMT2AHPGDTK1 | |
| SCHEMBL3918733 | 0.78 | KMT2A (0.39) | TYMPMAPK1KMT2AHPGDTK1 | |
| SCHEMBL6065649 | 0.77 | HPGD (0.42) | TYMPMAPK1HPGDTK1 | |
| SCHEMBL28985698 | 0.76 | MAPK1 (0.49) | TYMPMAPK1KMT2AHPGDTK1 | |
| SCHEMBL7550172 | 0.75 | TK1 (0.39) | MAPK1KMT2AHPGDTK1 | |
| SCHEMBL13319571 | 0.74 | MAPK1 (0.54) | TYMPMAPK1HPGDTK1 | |
| SCHEMBL17013819 | 0.73 | MAPK1 (0.56) | TYMPMAPK1HPGDTK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6756199-B1 | USED FOR THE SYNTHESIS OF BOTH PREDEFINED AND RANDOM SEQUENCE PEPTIDE NUCLEIC ACID OLIGOMERS | ISIS PHARMACEUTICALS, INC. | 2004-06-29 | — | — | US | disclosed |
| US-6204326-B1 | ADDING PEPTIDE NUCLEIC ACID UNITS TO AN AMINE TERMINATED PEPTIDE NUCLEIC ACID OLIGOMER ON A SOLID PHASE SYNTHETIC RESIN; BIOSYNTHESIS | ISIS PHARMACEUTICALS, INC. | 2001-03-20 | — | — | US | disclosed |
| EP-0777678-B1 | PNA COMBINATORIAL LIBRARIES AND IMPROVED METHODS OF SYNTHESIS | ISIS PHARMACEUTICALS INC (US) | 1999-10-13 | — | — | EP | disclosed |
| US-5539083-A | FROM HALOACETYL HALIDE OR SULFONYLACETYL HALIDE, PROTECTED ALKYLENEDIAMINE, AND A DERIVATIVE OF A NUCLEIC ACID BASE | ISIS PHARMACEUTICALS, INC. (US) | 1996-07-23 | — | — | US | disclosed |