Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TYMP | P19971 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TK1 | P04183 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7529481 | 0.89 | HPGD (0.43) | HPGDTYMPMAPK1TK1 | |
| SCHEMBL6837969 | 0.84 | TYMP (0.41) | HPGDTYMPMAPK1TK1 | |
| SCHEMBL8343325 | 0.79 | ALDH1A1 (0.43) | — | |
| SCHEMBL456749 | 0.77 | HPGD (0.57) | HPGDTYMPMAPK1TK1 | |
| SCHEMBL6837655 | 0.77 | TYMP (0.43) | HPGDTYMPMAPK1TK1 | |
| SCHEMBL7529489 | 0.77 | HPGD (0.43) | HPGDTYMPMAPK1TK1 | |
| SCHEMBL5349908 | 0.75 | TK1 (0.39) | HPGDTK1 | |
| SCHEMBL28985698 | 0.74 | MAPK1 (0.49) | HPGDTYMPMAPK1TK1 | |
| SCHEMBL157965 | 0.74 | TK2 (0.46) | TK1 | |
| SCHEMBL3931655 | 0.74 | TK2 (0.46) | TK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9095601-B2 | Cell permeable nanoconjugates of shell-crosslinked knedel (SCK) and peptide nucleic acids (“PNAs”) with uniquely expressed or over-expressed mRNA targeting sequences for early diagnosis and therapy of cancer | WASHINGTON UNIVERSITY IN ST. LOUIS (US) | 2015-08-04 | — | — | US | disclosed |
| US-20130230452-A1 | CELL PERMEABLE NANOCONJUGATES OF SHELL-CROSSLINKED KNEDEL (SCK) AND PEPTIDE NUCLEIC ACIDS (\"PNAs\") WITH UNIQUELY EXPRESSED OR OVER-EXPRESSED mRNA TARGETING SEQUENCES FOR EARLY DIAGNOSIS AND THERAPY OF CANCER | WASHINGTON UNIVERSITY (US) | 2013-09-05 | — | — | US | disclosed |
| US-8354093-B2 | Cell permeable nanoconjugates of shell-crosslinked knedel (SCK) and peptide nucleic acids (“PNAs”) with uniquely expressed or over-expressed mRNA targeting sequences for early diagnosis and therapy of cancer | WASHINGTON UNIVERSITY (US) | 2013-01-15 | — | — | US | disclosed |
| US-20060159619-A1 | Cell permeable nanoconjugates of shell-crosslinked knedel (SCK) and peptide nucleic acids (\"PNAs\") with uniquely expressed or over-expressed mRNA targeting sequences for early diagnosis and therapy of cancer | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2006-07-20 | — | — | US | disclosed |
| EP-0761681-B1 | Process for the preparation of substituted derivatives of N-ethylglycine | HOECHST AG (DE) | 2002-03-13 | — | — | EP | disclosed |
| US-5977296-A | MONOMERS WITH ALIPHATIC CYCLIC STRUCTURE IN THE BACKBONE; FOR INCREASED CONFORMATION RESTRICTION LEADING TO INCREASED BINDING AFFINITY AND SPECIFICITY; FOR DETECTING POINT MUTATIONS, FOR SUPPRESSING WILD TYPE GENES IN AMPLIFICATION | NIELSEN, PETER E. (DK) | 1999-11-02 | — | — | US | disclosed |
| US-5817811-A | AMIDATION OF THE CORRESPOND ESTERIFIED AMINE COMPOUND WITH A CARBOXYLATED NUCLEOTIDE BASE | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-10-06 | — | — | US | disclosed |
| EP-0761681-A2 | Process for the preparation of substituted derivatives of N-ethylglycine | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-03-12 | — | — | EP | disclosed |
| WO-1996020212-A2 | PEPTIDE NUCLEIC ACID INCORPORATING A CHIRAL BACKBONE | BUCHARDT, DORTE (DK) | 1996-07-04 | — | — | WO | disclosed |