SCHEMBL683879

SCHEMBL683879

COc1ccc(/C(C)=N/NC(=O)c2ccccc2Cl)c(O)c1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.65
GAA P10253 2/20 0.65
POLB P06746 1/20 0.65
APEX1 P27695 1/20 0.65
TDP1 Q9NUW8 1/20 0.65
KDM4E B2RXH2 4/20 0.55
SMN1; SMN2 Q16637 3/20 0.55
RAB9A P51151 2/20 0.55
NPC1 O15118 2/20 0.55
L3MBTL1 Q9Y468 1/20 0.55
MEN1 O00255 2/20 0.52
KMT2A Q03164 2/20 0.52
AGTR1 P30556 1/20 0.52
OPRK1 P41145 1/20 0.52
HTT P42858 2/20 0.52
CYP3A4 P08684 3/20 0.51
HPGD P15428 2/20 0.51
LMNA P02545 1/20 0.51
CYP1A2 P05177 1/20 0.51
PGR P06401 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL684586 0.91 KDM1A (0.55) MAPTGAAPOLBAPEX1TDP1
SCHEMBL685084 0.89 HPGD (0.62) MAPTGAAPOLBAPEX1TDP1
SCHEMBL684680 0.87 RAB9A (0.56) MAPTGAAPOLBAPEX1TDP1
SCHEMBL685049 0.86 RAB9A (0.55) MAPTGAAPOLBAPEX1TDP1
SCHEMBL685242 0.85 KDM1A (0.60) MAPTKDM4ESMN1; SMN2RAB9ANPC1
SCHEMBL684675 0.84 L3MBTL1 (0.63) MAPTGAAPOLBAPEX1TDP1
SCHEMBL684651 0.83 KDM1A (0.65) MAPTGAAPOLBKDM4ESMN1; SMN2
SCHEMBL685250 0.82 MAPT (0.57) MAPTGAAPOLBAPEX1TDP1
SCHEMBL685050 0.81 KDM4E (0.53) MAPTGAAPOLBAPEX1TDP1
SCHEMBL683881 0.81 L3MBTL1 (0.63) MAPTGAAPOLBAPEX1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120010075-A1 SYNERGISTIC FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER DOW AGROSCIENCES LLC (US) 2012-01-12 US disclosed
US-20120010075-A1 SYNERGISTIC FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER DOW AGROSCIENCES LLC (US) 2012-01-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120010075-A1 SYNERGISTIC FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER SOD1, CYP51A1, SOD3 MAPT 1491/4885GAA 670/4885POLB 4572/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.