Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | GRM8 | O00222 | 1/20 | 0.43 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | TTR | P02766 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.40 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6841592 | 0.89 | TDP1 (0.44) | MAPK1ALDH1A1SMN1; SMN2GPR35TP53 | |
| SCHEMBL9026753 | 0.81 | GRM8 (0.48) | MAPK1ALDH1A1SMN1; SMN2GPR35TP53 | |
| SCHEMBL11113945 | 0.81 | TDP1 (0.47) | MAPK1ALDH1A1SMN1; SMN2GPR35TP53 | |
| SCHEMBL9026746 | 0.80 | TDP1 (0.46) | MAPK1ALDH1A1SMN1; SMN2GPR35TP53 | |
| SCHEMBL20623073 | 0.80 | TDP1 (0.46) | MAPK1ALDH1A1SMN1; SMN2GPR35TP53 | |
| SCHEMBL2332862 | 0.77 | ALDH1A1 (0.53) | MAPK1ALDH1A1SMN1; SMN2GPR35TP53 | |
| SCHEMBL28052793 | 0.76 | ALDH1A1 (0.51) | MAPK1ALDH1A1SMN1; SMN2GPR35TP53 | |
| SCHEMBL10895136 | 0.74 | TDP1 (0.50) | MAPK1ALDH1A1SMN1; SMN2GPR35TP53 | |
| SCHEMBL14844208 | 0.74 | GRM8 (0.49) | MAPK1ALDH1A1SMN1; SMN2GPR35TP53 | |
| SCHEMBL8643545 | 0.73 | GRM8 (0.47) | MAPK1ALDH1A1SMN1; SMN2GPR35TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040266802-A1 | Tricyclic analgesics | CALVET ALAIN (US) | 2004-12-30 | — | — | US | disclosed |
| EP-1235808-A2 | TRICYCLIC ANALGESICS | WARNER-LAMBERT COMPANY (US) | 2002-09-04 | — | — | EP | disclosed |
| WO-2000075116-A2 | TRICYCLIC ANALGESICS | WARNER-LAMBERT COMPANY (US) | 2000-12-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040266802-A1 | Tricyclic analgesics | OPRM1, OPRL1, OPRD1 | MAPK1 1866/4885ALDH1A1 683/4885SMN1; SMN2 1008/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.