SCHEMBL684285

SCHEMBL684285

Cc1ccc(CC(C)NCCn2cnc3c2c(=O)n(C)c(=O)n3C)cc1

nearest known ligand 0.57

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
RXFP1 Q9HBX9 2/20 0.53
POLB P06746 1/20 0.53
GAA P10253 1/20 0.53
LMNA P02545 5/20 0.52
MAPK1 P28482 1/20 0.52
ALDH1A1 P00352 1/20 0.52
ADORA2B P29275 7/20 0.51
MAPT P10636 1/20 0.51
SMN1; SMN2 Q16637 3/20 0.51
TSHR P16473 1/20 0.50
ABCC8 Q09428 1/20 0.50
KCNJ11 Q14654 1/20 0.50
MEN1 O00255 1/20 0.49
KMT2A Q03164 1/20 0.49
HTT P42858 1/20 0.48
UBE2N P61088 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL683928 0.93 ADORA2B (0.55) RXFP1POLBGAALMNAMAPK1
SCHEMBL683563 0.92 ADORA2B (0.54) RXFP1POLBGAALMNAMAPK1
SCHEMBL682773 0.92 ADORA2B (0.54) RXFP1POLBGAALMNAMAPK1
SCHEMBL682774 0.90 LMNA (0.66) RXFP1LMNAMAPK1ALDH1A1ADORA2B
Fenethylline SCHEMBL149145 0.90 ALDH1A1 (0.65) RXFP1LMNAMAPK1ALDH1A1ADORA2B
Fenethylline SCHEMBL155920 0.89 ALDH1A1 (0.64) RXFP1LMNAMAPK1ALDH1A1ADORA2B
Fenethylline SCHEMBL121386 0.89 ALDH1A1 (0.64) RXFP1LMNAMAPK1ALDH1A1ADORA2B
SCHEMBL683984 0.89 RXFP1 (0.63) RXFP1LMNAMAPK1ALDH1A1ADORA2B
Fenethylline SCHEMBL14057908 0.86 ALDH1A1 (0.60) RXFP1POLBLMNAMAPK1ALDH1A1
Fenethylline SCHEMBL1934850 0.86 ALDH1A1 (0.60) RXFP1LMNAMAPK1ALDH1A1ADORA2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110269717-A1 NEUROGENESIS BY MODULATING ANGIOTENSIN BRAINCELLS INC. (US) 2011-11-03 US disclosed
US-20110269717-A1 NEUROGENESIS BY MODULATING ANGIOTENSIN BRAINCELLS INC. (US) 2011-11-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110269717-A1 NEUROGENESIS BY MODULATING ANGIOTENSIN NGF, DCX, BDNF RXFP1 211/4885POLB 1723/4885GAA 1899/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.