Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.58 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.48 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.41 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6217032 | 0.88 | RAB9A (0.54) | RAB9ANR1H4EGLN1NPC1POLB | |
| SCHEMBL6193923 | 0.86 | RAB9A (0.62) | RAB9ANR1H4EGLN1NPC1POLB | |
| SCHEMBL6195058 | 0.83 | CXCR3 (0.40) | RAB9ANPC1POLBCHRM4TAS1R3 | |
| SCHEMBL6212014 | 0.81 | NR1H4 (0.48) | NR1H4MAPTMMP13EPHX2 | |
| SCHEMBL6193966 | 0.81 | NR1H4 (0.48) | NR1H4MAPTMEN1MMP13KMT2A | |
| SCHEMBL6193523 | 0.80 | RAB9A (0.57) | RAB9ANR1H4EGLN1NPC1POLB | |
| SCHEMBL3033717 | 0.80 | RAB9A (0.70) | RAB9ANR1H4EGLN1NPC1POLB | |
| SCHEMBL6194056 | 0.79 | NR1H4 (0.68) | NR1H4ALDH1A1HPGDMMP13EPHX2 | |
| SCHEMBL6192845 | 0.79 | NR1H4 (0.60) | RAB9ANR1H4POLBALDH1A1MEN1 | |
| SCHEMBL6193273 | 0.79 | NR1H4 (0.60) | NR1H4LMNAKMT2AEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040043983-A1 | Naphthalene derivatives as matrix metalloproteinase inhibitors | LI JIE JACK (US) | 2004-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040043983-A1 | Naphthalene derivatives as matrix metalloproteinase inhibitors | MMP9, MMP8, MMP13 | RAB9A 976/4885NR1H4 1615/4885EGLN1 2984/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.