Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.59 |
| ▸ | BMP1 | P13497 | 1/20 | 0.52 |
| ▸ | MMP3 | P08254 | 3/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.46 |
| ▸ | NCOR2 | Q9Y618 | 3/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.46 |
| ▸ | MMP1 | P03956 | 7/20 | 0.45 |
| ▸ | MMP13 | P45452 | 7/20 | 0.45 |
| ▸ | MMP9 | P14780 | 3/20 | 0.45 |
| ▸ | MMP7 | P09237 | 4/20 | 0.45 |
| ▸ | MMP12 | P39900 | 4/20 | 0.45 |
| ▸ | ACE | P12821 | 2/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | MMP8 | P22894 | 3/20 | 0.44 |
| ▸ | MMP2 | P08253 | 2/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | ICMT | O60725 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8037741 | 1.00 | CNR2 (0.59) | CNR2BMP1MMP3HDAC1HDAC3 | |
| SCHEMBL8038065 | 1.00 | CNR2 (0.59) | CNR2BMP1MMP3HDAC1HDAC3 | |
| SCHEMBL9307806 | 0.86 | CNR2 (0.71) | CNR2EPHX2ICMTALBMEN1 | |
| SCHEMBL8038085 | 0.85 | BMP1 (0.69) | CNR2BMP1MMP3HDAC1MMP1 | |
| SCHEMBL8027608 | 0.85 | MMP3 (0.53) | CNR2BMP1MMP3HDAC1HDAC3 | |
| SCHEMBL8027595 | 0.85 | BMP1 (0.69) | CNR2BMP1MMP3HDAC1MMP1 | |
| SCHEMBL8038049 | 0.85 | BMP1 (0.62) | CNR2BMP1MMP3HDAC1HDAC3 | |
| SCHEMBL8039632 | 0.85 | MMP3 (0.57) | BMP1MMP3HDAC1HDAC3HDAC2 | |
| SCHEMBL6411529 | 0.82 | BMP1 (0.53) | CNR2BMP1MMP3HDAC1HDAC3 | |
| SCHEMBL8041116 | 0.82 | MMP2 (0.55) | MMP3MMP1MMP13MMP9MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040176393-A1 | Statin-MMP inhibitor combinations | NEWTON ROGER SCHOFIELD (US) | 2004-09-09 | — | — | US | disclosed |
| US-6124329-A | AN ENZYME INHIBITOR FOR THE TREATMENT OR PROPHYLAXIS OF TISSUE BREAKDOWN, FOR EXAMPLE RHEUMATOID ARTHRITIS, OSTEOPOROSIS, PERIODONTITIS, GINGIVITIS, CORNEAL EPIDERMAL OR GASTRIC ULCERATION, AND TUMOR, MULTIPLE SCLEROSIS | BRITISH BIOTECH PHARMACEUTICALS LTD. (GB) | 2000-09-26 | — | — | US | disclosed |
| EP-0766664-B1 | METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARM (GB) | 2000-04-05 | — | — | EP | disclosed |
| EP-0766664-A2 | METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1997-04-09 | — | — | EP | disclosed |
| WO-1995035275-A1 | METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1995-12-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040176393-A1 | Statin-MMP inhibitor combinations | MMP9, TIMP3, MMP3 | CNR2 4148/4885BMP1 922/4885MMP3 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.