Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.74 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.64 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.60 |
| ▸ | AKT1 | P31749 | 1/20 | 0.60 |
| ▸ | MAOB | P27338 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.54 |
| ▸ | IKBKB | O14920 | 1/20 | 0.53 |
| ▸ | CHUK | O15111 | 1/20 | 0.53 |
| ▸ | IKBKG | Q9Y6K9 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6844087 | 1.00 | NFE2L2 (0.74) | NFE2L2TRPM8CYP1A1CYP1A2CYP2D6 | |
| SCHEMBL6776487 | 0.87 | NFE2L2 (0.79) | NFE2L2TRPM8CYP1A1CYP1A2CYP2D6 | |
| SCHEMBL1056670 | 0.87 | NFE2L2 (0.79) | NFE2L2TRPM8CYP1A1CYP1A2CYP2D6 | |
| SCHEMBL457033 | 0.87 | NFE2L2 (0.79) | NFE2L2TRPM8CYP1A1CYP1A2CYP2D6 | |
| SCHEMBL2744353 | 0.85 | NFE2L2 (1.00) | NFE2L2TRPM8CYP1A1CYP1A2CYP2D6 | |
| SCHEMBL30842599 | 0.85 | NFE2L2 (0.72) | NFE2L2TRPM8CYP1A1CYP1A2CYP2D6 | |
| SCHEMBL21067352 | 0.85 | NFE2L2 (0.72) | NFE2L2TRPM8CYP1A1CYP1A2CYP2D6 | |
| SCHEMBL21067353 | 0.85 | NFE2L2 (0.72) | NFE2L2TRPM8CYP1A1CYP1A2CYP2D6 | |
| SCHEMBL2744350 | 0.85 | NFE2L2 (1.00) | NFE2L2TRPM8CYP1A1CYP1A2CYP2D6 | |
| SCHEMBL14950768 | 0.84 | NFE2L2 (0.79) | NFE2L2TRPM8CYP1A1CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0534536-B1 | Process for the preparation of 2-amino-5,6-dimethoxy-tetralin | ZAMBON SPA (IT) | 1996-01-31 | — | — | EP | claimed |
| US-5221770-A | PROCESS FOR THE PREPARATION OF 2-AMINO-5,6-DIMETHOXY-TETRALIN | ZAMBON GROUP S.P.A. (IT) | 1993-06-22 | — | — | US | claimed |
| EP-0534536-A2 | Process for the preparation of 2-amino-5,6-dimethoxy-tetralin | ZAMBON GROUP S.p.A. (IT) | 1993-03-31 | — | — | EP | claimed |
| JP-5201939-A | — | — | None | — | — | JP | disclosed |
| US-20040102652-A1 | Optically active2-aminotetralin derivatives, the processes for the preparation thereof and the therapeutical use of pharmaceutical compositions containing them | CHIESI FARMACEUTICI S.P.A. (IT) | 2004-05-27 | — | — | US | disclosed |
| EP-1280759-A1 | OPTICALLY ACTIVE 2-AMINOTETRALIN DERIVATIVES, THE PROCESSES FOR THE PREPARATION THEREOF AND THE THERAPEUTICAL USE OF PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | CHIESI FARMACEUTICI S.p.A. (IT) | 2003-02-05 | — | — | EP | disclosed |
| EP-0781126-B1 | DERIVATIVES OF 2-AMINO-1,2,3,4-TETRAHYDRO-NAPHTHALENE ACTIVE ON THE CARDIOVASCULAR SYSTEM | ZAMBON SPA (IT) | 2001-12-12 | — | — | EP | disclosed |
| WO-2001085668-A1 | OPTICALLY ACTIVE 2-AMINOTETRALIN DERIVATIVES, THE PROCESSES FOR THE PREPARATION THEREOF AND THE THERAPEUTICAL USE OF PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | CHIESI FARMACEUTICI S.P.A. (IT) | 2001-11-15 | — | — | WO | disclosed |
| EP-1091958-A1 | SALTS OF PAROXETINE | SMITHKLINE BEECHAM PLC (GB) | 2001-04-18 | — | — | EP | disclosed |
| EP-0788472-B1 | A PROCESS FOR THE PREPARATION OF 5,6-DIHYDROXY-2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALENE DERIVATIVES | CHIESI FARMA SPA (IT) | 2000-08-02 | — | — | EP | disclosed |
| US-6034277-A | Process for the preparation of 5,6-dihydroxy-2-amino-1,2,3,4-tetrahydronaphthalene derivatives | CHIESI FARMACEUTICI S.P.A. (IT) | 2000-03-07 | — | — | US | disclosed |
| US-5710336-A | Process for the preparation of 5-6-dihydroxy-2-amino-1, 2, 3, 4-tetrahydronaphthalene derivatives | CHIESI FARMACEUTICI S.P.A. (IT) | 1998-01-20 | — | — | US | disclosed |
| EP-0788472-A1 | A PROCESS FOR THE PREPARATION OF 5,6-DIHYDROXY-2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALENE DERIVATIVES | CHIESI FARMACEUTICI S.p.A. (IT) | 1997-08-13 | — | — | EP | disclosed |
| EP-0781126-A2 | DERIVATIVES OF 2-AMINO-1,2,3,4-TETRAHYDRO-NAPHTHALENE ACTIVE ON THE CARDIOVASCULAR SYSTEM | ZAMBON GROUP S.p.A. (IT) | 1997-07-02 | — | — | EP | disclosed |
| WO-1996008228-A2 | DERIVATIVES OF 2-AMINO-1,2,3,4-TETRAHYDRO-NAPHTHALENE ACTIVE ON THE CARDIOVASCULAR SYSTEM | ZAMBON GROUP S.P.A. (IT) | 1996-03-21 | — | — | WO | disclosed |
| EP-0534536-B1 | Process for the preparation of 2-amino-5,6-dimethoxy-tetralin | ZAMBON SPA (IT) | 1996-01-31 | — | — | EP | disclosed |
| WO-1995029147-A1 | A PROCESS FOR THE PREPARATION OF 5,6-DIHYDROXY-2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALENE DERIVATIVES | CHIESI FARMACEUTICI S.P.A. (IT) | 1995-11-02 | — | — | WO | disclosed |
| JP-H05201939-A | PRODUCTION OF 2-AMINO-5,6-DIMETHOXY TETRALIN | ZAMBON GROUP SPA | 1993-08-10 | — | — | JP | disclosed |
| US-5221770-A | PROCESS FOR THE PREPARATION OF 2-AMINO-5,6-DIMETHOXY-TETRALIN | ZAMBON GROUP S.P.A. (IT) | 1993-06-22 | — | — | US | disclosed |
| EP-0534536-A2 | Process for the preparation of 2-amino-5,6-dimethoxy-tetralin | ZAMBON GROUP S.p.A. (IT) | 1993-03-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040102652-A1 | Optically active2-aminotetralin derivatives, the processes for the preparation thereof and the therapeutical use of pharmaceutical compositions containing them | AADAT, AASDHPPT, AAAS | NFE2L2 1883/4885TRPM8 2926/4885CYP1A1 366/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.